Sialyllacto-N-neotetraose c | 64003-55-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Sialyllacto-N-neotetraose c
• 英文别名: (2R,4S,5R,6R)-5-acetamido-2-[[(3R,4S,5R,6S)-6-[(2R,3S,4R,5R,6S)-5-acetamido-6-[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
• CAS: 64003-55-0
• 化学式: C₃₇H₆₂N₂O₂₉
• 分子量: 998.9
• InChiKey: SXMGGNXBTZBGLU-IBUUTZGMSA-N

物化性质

• 沸点：
  1446.9±65.0 °C(Predicted)
• 密度：
  1.74±0.1 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -11.8
• 重原子数：
  68
• 可旋转键数：
  22
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  510
• 氢给体数：
  19
• 氢受体数：
  29

文献信息

• Retargeting of viruses or VLPs
  申请人：Deutsches Primatenzentrum GmbH Leibniz-Institut für Primatenforschung

  公开号：US10975359B2

  公开（公告）日：2021-04-13

  The present invention relates to a method of producing a polyomavirus or polyomavirus-derived virus-like particle (vlp) carrying on its surface at least one targeting molecule that binds to a cell of interest. Furthermore, the present invention relates to a composition comprising such a polyomavirus or polyomavirus-derived vlp and to the use of the polyomavirus or polyomavirus-derived vlp of the invention or the composition of the invention for use as a medicament. The present invention further relates to a kit comprising the polyomavirus or polyomavirus-derived vlp or the composition of the invention.

  本发明涉及一种生产多瘤病毒或多瘤病毒衍生病毒样颗粒（vlp）的方法，该病毒样颗粒表面携带至少一种与相关细胞结合的靶向分子。此外，本发明还涉及一种包含这种多瘤病毒或多瘤病毒衍生的病毒样颗粒的组合物，以及本发明的多瘤病毒或多瘤病毒衍生的病毒样颗粒或本发明的组合物作为药物的用途。本发明还涉及一种包含多瘤病毒或多瘤病毒衍生 vlp 或本发明组合物的试剂盒。
• RETARGETING OF VIRUSES OR VLPS
  申请人：Deutsches Primatenzentrum GmbH (DPZ) - Leibniz-Institut für Primatenforschung

  公开号：EP3577217B1

  公开（公告）日：2021-04-14
• RETARGETING OF VIRUSES OR VLPs
  申请人：DEUTSCHES PRIMATENZENTRUM GMBH (DPZ) - LEIBNIZ-INSTITUT FÜR PRIMATENFORSCHUNG

  公开号：US20190352617A1

  公开（公告）日：2019-11-21

  The present invention relates to a method of producing a polyomavirus or polyomavirus-derived virus-like particle (VLP) carrying on its surface at least one targeting molecule that binds to a cell of interest, the method comprising the step of contacting the polyomavirus or polyomavirus-derived VLP with (i) the targeting molecule, wherein the at least one targeting molecule is glycosylated with at least one glycosyl residue that is recognised by the polyomavirus or polyomavirus-derived VLP; or (ii) a first interaction molecule, wherein the first interaction molecule is glycosylated with at least one glycosyl residue that is recognised by the polyomavirus or polyomavirus-derived VLP; and the at least one targeting molecule, wherein the at least one targeting molecule is conjugated to a second interaction molecule capable of interacting with the first interaction molecule. The present invention further relates to a polyomavirus or polyomavirus-derived virus-like particle (VLP), wherein the virus or VLP carries on its surface at least one targeting molecule that binds to a cell of interest, as well as to a polyomavirus or polyomavirus-derived VLP obtained or obtainable by the method of the invention. Furthermore, the present invention relates to a composition comprising said polyomavirus or polyomavirus-derived VLP and to the use of the polyomavirus or polyomavirus-derived VLP of the invention or the composition of the invention for use as a medicament. The present invention further relates to a kit comprising the polyomavirus or polyomavirus-derived VLP or the composition of the invention.