4,6-二溴-1,3-二乙酰苯胺 | 132530-67-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4,6-二溴-1,3-二乙酰苯胺
• 英文名称: 1,3-dibromo-4,6-bis(acetamido)benzene
• 英文别名: 1,5-bis(acetamido)-2,4-dibromobenzene；4,6-dibromo-1,3-phenylenediacetamide；N,N'-(4,6-dibromo-m-phenylene)-bis-acetamide；N,N'-(4,6-Dibrom-m-phenylen)-bis-acetamid；N.N'-Diacetyl-4.6-dibrom-phenylendiamin-(1.3)；N-(5-acetamido-2,4-dibromophenyl)acetamide
• CAS: 132530-67-7
• 化学式: C₁₀H₁₀Br₂N₂O₂
• 分子量: 350.01
• InChiKey: ZESMJYDAJIBPHA-UHFFFAOYSA-N

物化性质

• 沸点：
  513.0±50.0 °C(Predicted)
• 密度：
  1.862±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302
• 储存条件：
  室温且干燥环境下使用。

反应信息

• 作为反应物：
  描述：

  4,6-二溴-1,3-二乙酰苯胺 在 四(三苯基膦)钯 、 palladium diacetate 、 potassium carbonate 、 tricyclohexylphosphine tetrafluoroborate 作用下， 以 N,N-二甲基乙酰胺 、 水 、 甲苯 为溶剂， 反应 32.0h， 生成 5,7-二氢-吲哚并[2,3-B]咔唑
  参考文献：
  名称：

  Indolo[2,3-b]carbazole Synthesized from a Double-Intramolecular Buchwald–Hartwig Reaction: Its Application for a Dianchor DSSC Organic Dye

  摘要：

  A new synthetic strategy for indolo[2,3-b]carbazole via a double-intramolecular Buchwald-Hartwig reaction has been established. The N-alkylated indolo[2,3-b]carbazole then was adopted as the geometry-fixed core for the synthesis of a new molecule (ICZDTA) bearing two bithiophene π-bridged 2-cyanoacrylic acid groups as the bidentate anchor. The bidentate anchoring together with efficient HOMO (indolo[2,3-b]carbazole) → LUMO (TiO2 nanocluster) electron transfer leads to the successful development of ICZDTA-based DSSC with a power conversion efficiency of 6.02%.

  DOI：

  10.1021/ol500663b
• 作为产物：
  描述：

  N-(3-乙酰氨基苯基)乙酰胺 在 溶剂黄146 作用下， 生成 4,6-二溴-1,3-二乙酰苯胺
  参考文献：
  名称：

  Morgan; Wootton, Journal of the Chemical Society, 1905, vol. 87, p. 938

  摘要：

  DOI：

文献信息

• Cyclization of Acetylenic Amides Using a Cationic Rhodium(I) Complex
  作者：Suzanne Burling、Leslie D. Field、Hsiu L. Li、Barbara A. Messerle、Adelle Shasha

  DOI：10.1071/ch04032

  日期：——

  The cationic Rh(I) dicarbonyl complex [Rh(bim)(CO)2}+BPh4–] 1, containing a bidentate bisimidazolylmethane ligand [bim refers to bis(N-methylimidazol-2-yl)methane] acts as a catalyst for the cyclization of alkynyl amides to produce lactams and N-acyl heterocyclic compounds.

  阳离子 Rh(I) 二羰基配合物 [Rh(bim)(CO)2}+BPh4–] 1，含有二齿双咪唑基甲烷配体 [bim 指双(N-甲基咪唑-2-基)甲烷] 作为催化剂用于炔基酰胺环化生成内酰胺和N-酰基杂环化合物。
• Intramolecular cyclization of ortho-alkynylanilines by Rh(I)-catalyzed hydroamination to yield benzo(dipyrroles)
  作者：Guy K.B. Clentsmith、Leslie D. Field、Barbara A. Messerle、Adelle Shasha、Peter Turner

  DOI：10.1016/j.tetlet.2009.01.060

  日期：2009.4

  The methylene-bridged Rh(1) dicarbonyl complex, [Rh(bim)(CO)(2) BPh4 (1) (bim = bis(N-methylimidazol-2-yl)methane), is an effective catalyst for the intramolecular hydroamination of selected ortho-alkynylanilines to give a range of benzo(dipyrroles). (C) 2009 Elsevier Ltd. All rights reserved.
• Chattaway; Orton, Chemische Berichte, 1901, vol. 34, p. 163
  作者：Chattaway、Orton

  DOI：——

  日期：——
• Functional school refusal subtypes: Anxiety, avoidance, and malingering
  作者：Larry D. Evans

  DOI：10.1002/(sici)1520-6807(200003)37:2<183::aid-pits9>3.0.co;2-5

  日期：2000.3

  Chronic school refusal has traditionally been classified under broad categories such as school phobia and truancy. However, the need for improved recognition and treatment of school refusal has heightened efforts to identify subtypes of school refusal behavior. Recent efforts have focused on functional subtypes of school refusal. This article purposes to extend recent efforts by showing that the three basic subtypes of anxiety, avoidance, and malingering are not only functional, bur consistent with refusal characteristics, empirical evidence from factor analysis and clinical diagnosis over the past decade, and treatment approaches. Such extension is intended to aid practitioners in further understanding and using functional subtypes. (C) 2000 John Wiley & Sons, Inc.
• Jackson; Calvert, American Chemical Journal, 1896, vol. 18, p. 470
  作者：Jackson、Calvert

  DOI：——

  日期：——