串珠镰刀菌素钾盐 | 71376-34-6

• 物质功能分类: 分析化学 - 标准品 - 食品和化妆品标准品
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 乙烯基酸
• 中文名称: 串珠镰刀菌素钾盐
• 中文别名: 串珠镰刀菌素
• CAS: 71376-34-6
• 化学式: C4H2NaO3
• 分子量: 121.05
• InChiKey: YZWMNRPZLOLKPI-UHFFFAOYSA-N

物化性质

• 闪点：
  2℃
• 溶解度：
  水中≤10mg/ml

计算性质

• 辛醇/水分配系数(LogP)：
  -1.39
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险品标志：
  T
• 安全说明：
  S45
• 危险类别码：
  R25
• WGK Germany：
  2,3
• 海关编码：
  29144000

制备方法与用途

毒性

串珠镰刀菌素对动物有较强的毒性作用，主要作用于增殖活跃的细胞，例如心肌、肝、脾、骨骼肌以及软骨细胞和骨细胞等。

生物活性

Moniliformin sodium salt是提取自镰孢镰刀菌中的有效，水溶性的霉菌毒素。

体外研究

Fusarium moniliforme NRRL 6322 produces about 600 mg of recoverable moniliformin, a mycotoxic metabolite, per kg of corn grit medium. Several strains of Fusarium moniliforme produce in laboratory culture more than 800 mg of moniliformin per kg of growth substrate. Monocytes-derived macrophages exposed to moniliformin during the differentiation process present a decrease of endocytosis ability, and a decrease of CD71 and HLA-DR expression.

体内研究

Moniliformin is less toxic to mice, with an LD ₅₀ of 20.9 mg per kg for the females and 29.1 mg per kg of body weight for the males. As in the case of the chicks, mice surviving the toxin demonstrated no ill effects; the mice or chicks that died became recumbent in 4 to 6 h after treatment and died within 24 h. In 4-day-old chicken embryos, a sharp LD ₅₀ of 2.8 μg per embryo is obtained with no overt gross teratogenic effects in the survivors. Rats treated with the highest dose of moniliformin show decreased activity followed by acute heart failure and death. The rats of the lower doses (<9mg/kg b.w.) show no signs of toxicity. The daily intake of moniliformin strongly reduces the phagocytic activity of neutrophils in all dose groups. The decrease continued in the satellite group during the follow-up period, indicating a severe impact on the immune system and a LOAEL value of 3mg/kg b.w. for moniliformin. Moniliformin is rapidly excreted into urine, ranging between 20.2 and 31.5% daily and shows no signs of accumulation. The concentration of moniliformin in faeces is less than 2%, which suggests efficient absorption from the gastrointestinal tract.