(2R,3S,4R,5R,6R)-2-Hydroxymethyl-6-isopropyl-tetrahydro-pyran-3,4,5-triol | 94939-99-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4R,5R,6R)-2-Hydroxymethyl-6-isopropyl-tetrahydro-pyran-3,4,5-triol
• 英文别名: (2R,3S,4R,5R,6R)-2-(hydroxymethyl)-6-propan-2-yloxane-3,4,5-triol
• CAS: 94939-99-8
• 化学式: C₉H₁₈O₅
• 分子量: 206.239
• InChiKey: XPNJNHGFUZJXNP-SYHAXYEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• ENTEROBACTIN CONJUGATES AND USES THEREOF
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：US20150105337A1

  公开（公告）日：2015-04-16

  The present invention provides novel enterobactin-cargo conjugates, such as compounds of Formula (I), and salts thereof, where X is the cargo and may be an antibiotic, a fluorophore, or biotin. The present invention also provides complexes, compositions, kits, and methods that involve the compounds of Formula (I) and are useful in delivering a cargo to a bacterium, treating a bacterial infection, cystic fibrosis, and/or inflammatory bowel disease in a subject, preventing a bacterial infection, cystic fibrosis, and/or inflammatory bowel disease in a subject, inhibiting the growth of or killing a bacterium, or determining the concentration of a bacterium in a biological sample. In certain embodiments, the bacterium is a Gram-negative bacterium.

  本发明提供了新型肠杆菌铁胞内载体共轭物，如式(I)化合物及其盐，其中X是载体，可以是抗生素、荧光素或生物素。本发明还提供了涉及式(I)化合物的络合物、组合物、试剂盒和方法，用于将载体传递给细菌，治疗受试者的细菌感染、囊性纤维化和/或炎症性肠病，预防受试者的细菌感染、囊性纤维化和/或炎症性肠病，抑制或杀死细菌的生长，或确定生物样品中细菌的浓度。在某些实施例中，细菌是革兰氏阴性细菌。
• DUAL PROTECTED PRO-COELENTERAZINE SUBSTRATES
  申请人：PROMEGA CORPORATION

  公开号：US20180072781A1

  公开（公告）日：2018-03-15

  Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.

  描述了腔肠素类似物、制备该类似物的方法、包含该类似物的试剂盒，以及利用这些化合物进行基于荧光素酶的检测的方法。
• US9902986B2
  申请人：——

  公开号：US9902986B2

  公开（公告）日：2018-02-27
• [EN] DUAL PROTECTED PRO-COELENTERAZINE SUBSTRATES<br/>[FR] SUBSTRATS DE PRO-COELENTÉRAZINE À DOUBLE PROTECTION
  申请人：PROMEGA CORP

  公开号：WO2018049241A1

  公开（公告）日：2018-03-15

  Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.