pentaethylene glycol heptyl ether | 65316-79-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: pentaethylene glycol heptyl ether
• 英文别名: 2-(2-{2-[2-(2-heptyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol；pentaethylene glycol monoheptyl ether；3,6,9,12,15-Pentaoxadocosan-1-ol；2-[2-[2-[2-(2-heptoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
• CAS: 65316-79-2
• 化学式: C₁₇H₃₆O₆
• 分子量: 336.469
• InChiKey: ISVAZCGDYSMKBE-UHFFFAOYSA-N

物化性质

• 沸点：
  420.6±35.0 °C(Predicted)
• 密度：
  0.994±0.06 g/cm3(Predicted)
• 保留指数：
  2387.7

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  23
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 海关编码：
  2909499000

文献信息

• COMPOSITIONS AND METHODS FOR MEMBRANE PROTEIN DETERGENT STABILITY SCREEN
  申请人：Wiener Michael C.

  公开号：US20120108463A1

  公开（公告）日：2012-05-03

  The invention provides methods to assess protein stability and to obtain sizing information. In one aspect, the screen comprises a 94 detergent panel and a series of MWCO filtered microplates. A protein of interest is bound to an affinity matrix and aliquoted into a 96-well microplate. Wells containing the immobilized protein are washed in the new detergent and then eluted in the new detergent into a collection plate. Protein not stable in the new detergent is precipitated on the resin and not present in the elutions. Half of the elution is passed through a high (i.e., 300 kDa) MWCO microplate and the other half through a low (i.e., 100 kDa) MWCO microplate. Elutions from the microplates are spotted on a nitrocellulose membrane, visualized by Western analysis (or by some other method), and quantified. The high MWCO provides stability readout and the ratio of low/high kDa provides sizing information.
• US9606126B2
  申请人：——

  公开号：US9606126B2

  公开（公告）日：2017-03-28
• [EN] COMPOSITIONS AND METHODS FOR MEMBRANE PROTEIN DETERGENT STABILITY SCREEN<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR UN CRIBLE DE LA STABILITÉ AUX DÉTERGENTS D'UNE PROTÉINE DE MEMBRANE
  申请人：UNIV VIRGINIA

  公开号：WO2011008528A2

  公开（公告）日：2011-01-20

  The invention provides methods to assess protein stability and to obtain sizing information. In one aspect, the screen comprises a 94 detergent panel and a series of MWCO filtered microplates. A protein of interest is bound to an affinity matrix and aliquoted into a 96-well microplate. Wells containing the immobilized protein are washed in the new detergent and then eluted in the new detergent into a collection plate. Protein not stable in the new detergent is precipitated on the resin and not present in the elutions. Half of the elution is passed through a high (i.e., 300 kDa) MWCO microplate and the other half through a low (i.e., 100 kDa) MWCO microplate. Elutions from the microplates are spotted on a nitrocellulose membrane, visualized by Western analysis (or by some other method), and quantified. The high MWCO provides stability readout and the ratio of low/high kDa provides sizing information.