2,3-O-Isopropyliden-β-D-ribofuranonsaeure | 68673-90-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3-O-Isopropyliden-β-D-ribofuranonsaeure
• 英文别名: (3aR,4R,6S,6aS)-4-hydroxy-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxole-6-carboxylic acid
• CAS: 68673-90-5
• 化学式: C₈H₁₂O₆
• 分子量: 204.18
• InChiKey: FAKXAHAZULMTIP-LPWFLVPJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] DIHYDROISOXAZOLYL SUBSTITUTED TETRAHYDROFURAN COOMPOUNDS AS INTERMEDIATES IN THE PREPARATION OF 2-(PURIN-9-YL) - TETRAHYDROFURAN DERIVATIVES<br/>[FR] COMPOSES DE TETRAHYDROFURAN DE DIHYDROISOXAZOLYLE SUBSTITUES UTILISES EN TANT QU'INTERMEDIAIRE DANS LA PREPARATION DE DERIVES DE 2-(PURINE-9-YL) - TETRAHYDROFURAN
  申请人：GLAXO GROUP LTD

  公开号：WO2003080604A1

  公开（公告）日：2003-10-02

  Dihydroisoxazolyl substituted Tetrahydrofuran compounds as intermediates in the preparation of 2 (puxin-9-y1)-tetrahydrofuran derivatives A process for preparing a compound of formula (I) which comprises dehydration of a compound of formula (II) according to Step (i): wherein R1 represents methyl, ethyl, -CH=CP2, n-propyl, -CH2FH=CH2, -CH=CHCH3, isopropyl, isopropenyl, cyclopropyl, cyclopropenyl, cyclôpropylmethyl, cyclopropenylmethyl, -CH (OH) CH3, - (CH2) q halogen, - (CH 2) hY (CH2) iH, - (CH2) kZ, - (CH2)hCO(CH2)oH, - (CH2)rS (O) t (CH2) sH or - (CH 2 )kC( (CH2)uH)=NO(CH2)vH; wherein Y represents O, S or NH (CH2)j; Z represents -COO(CH2)1H or -CON (CH2)mH((CH2)nH); q represents an intégér 0 to 3; h represents an integer 0 to 2; i represents an integer 0 to 2 such that h+i is in the range 0 to 3; j represents an integer 0 to 2 such that h+i+j is in the range 0 to 3; k represents 0 or 1; 1 represents 1 or 2, such that k+ 1 is in the range 1 to 2; m and n independently represent an integer 0 to 2 such that k+m+n is in the range 0 to 2; o represents an integer 0 to 2 such that h+o is in the range 0 to 2; r and s independently represent 1 or 2 such that r+s is in the range 2 to 3; t represents 1 or 2; u and v independently represent 0 or 1 such that k+u+v is in the range O to 1; L1 and L2 represent hydroxy or a protected derivative' thereof; and L3 represent a leaving group.
• [EN] PROCESS FOR THE PREPARATION OF INTERMEDIATES IN THE SYNTHESIS OF 2- (PURIN-9-YL) - TETRAHYDROFURAN-3,4-DIOL DERIVATIVES<br/>[FR] PROCEDES POUR LA PREPARATION D'INTERMEDIAIRES DANS LA SYNTHESE DE DERIVES DE 2-(PURINE-9-YL)-TERTRAHYDROFURAN-3,4-DIOL
  申请人：GLAXO GROUP LTD

  公开号：WO2003080613A1

  公开（公告）日：2003-10-02

  A process for preparing a compound of formula (II) Which comprises reacting a compound of formula (IV) wherein P1 represents a protecting group which is a cyclic ether connected to the purine ring nitrogen in the 2-position, or a salt thereof, with a compound of formula (V) R2NH2 (V) followed by deprotection and optional salt conversion to yield the compound of formula (II) or a salt thereof.