4-Isopropyloxy-1-methyl-pyrazol | 15131-96-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Isopropyloxy-1-methyl-pyrazol
• 英文别名: 4-isopropoxy-1-methyl-1H-pyrazole；1-methyl-4-(propan-2-yloxy)-1H-pyrazole；1-methyl-4-propan-2-yloxypyrazole
• CAS: 15131-96-1
• 化学式: C₇H₁₂N₂O
• 分子量: 140.185
• InChiKey: NQLUCQLEWFDDGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Covalent inhibitors of KRAS
  申请人：Araxes Pharma LLC

  公开号：US10745385B2

  公开（公告）日：2020-08-18

  Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R1, R2a, R2b, R2c, R3a, R3b, R4a, R4b, R5, L1, L2, L3, E, m1, m2 and * are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

  本研究提供了具有抑制 G12C 突变 KRAS 蛋白活性的化合物。这些化合物具有以下结构 (I)： 或其药学上可接受的盐、立体异构体、同位素形式或原药，其中 R1、R2a、R2b、R2c、R3a、R3b、R4a、R4b、R5、L1、L2、L3、E、m1、m2 和 * 如本文所定义。还提供了与制备和使用此类化合物相关的方法、包含此类化合物的药物组合物以及调节 G12C 突变 KRAS 蛋白活性以治疗疾病（如癌症）的方法。
• Substituted quinazoline compounds and methods of use
  申请人：ARAXES PHARMA LLC

  公开号：US10822312B2

  公开（公告）日：2020-11-03

  The present disclosure provides inhibitors of Ras protein of Formula (I-A): Also disclosed are methods to modulate the activity of Ras protein and methods of treatment of disorders mediated by Ras protein with compounds of Formula (I-A).

  本公开提供了式 (I-A) 的 Ras 蛋白抑制剂： 还公开了用式（I-A）化合物调节 Ras 蛋白活性的方法和治疗由 Ras 蛋白介导的疾病的方法。
• SUBSTITUTED QUINAZOLINE COMPOUNDS AND METHODS OF USE
  申请人：ARAXES PHARMA LLC

  公开号：US20190127336A1

  公开（公告）日：2019-05-02

  The present disclosure provides inhibitors of Ras protein. Also disclosed are methods to modulate the activity of Ras protein and methods of treatment of disorders mediated by Ras protein.