4-phenylamino-5-acetyl-1-phenyl-6-methyl-1H-pyrimidin-2-one | 139057-07-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-phenylamino-5-acetyl-1-phenyl-6-methyl-1H-pyrimidin-2-one
• 英文别名: 5-Acetyl-4-anilino-6-methyl-1-phenylpyrimidin-2-one
• CAS: 139057-07-1
• 化学式: C₁₉H₁₇N₃O₂
• 分子量: 319.363
• InChiKey: GULXGSDQLKPPCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  61.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,4-戊二酮,3-[氨基(苯基氨基)亚甲基]- 、 异氰酸苯酯 以 甲苯 为溶剂， 反应 6.0h， 以64%的产率得到4-phenylamino-5-acetyl-1-phenyl-6-methyl-1H-pyrimidin-2-one
  参考文献：
  名称：

  Synthesis of derivatives of 4-alkylthiouracil, cytosine, pyrido[2,3-d]pyrimidine, and pyrimido[4,5-d]pyrimidine from the N,S- and N,N-acetals of diacetylketene and isocyanates

  摘要：

  The action of alkyl and aryl isocyanates on the N,S-acetals of diacetylketene leads to the formation of 4-alkylthio-5-acetyl-1-alkyl(aryl)-6-methyl-1H-pyrimidin-2-ones (derivatives of 4-alkylthiouracils). The reaction of the synthesized thiouracils with amines or the reaction of the N,N-acetals of diacetylketene (N,N-ADK) with an equimolar amount of aryl isocyanates leads to the formation of substituted 4-amino-5-acetyl-1H-pyrimidin-2-ones derivatives of cytosine). From the latter and isocyanates or directly from N,N-ADK and an excess of the isocyanate, derivatives of 4-methylene-1H,3H,4H-pyrimido[4,5-d]pyrimidine-2,7-dione were obtained. The exception was the condensation of 3-[N-(4,6-dimethyl-2-pyrimidinyl)diaminomethylene]pentane-2,4-dione with aryl isocyanates, which led to 3H,8H-pyrido[2,3-d]pyrimidine-2,5-diones.

  DOI：

  10.1007/bf00961050