6-bromo-N-(2-chlorophenyl)imidazo[1,2-a]pyridine-3-carboxamide | 1250946-54-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-bromo-N-(2-chlorophenyl)imidazo[1,2-a]pyridine-3-carboxamide
• CAS: 1250946-54-3
• 化学式: C₁₄H₉BrClN₃O
• 分子量: 350.602
• InChiKey: UGAXSSCVORPHJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-bromo-N-(2-chlorophenyl)imidazo[1,2-a]pyridine-3-carboxamide 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 四(三苯基膦)钯 、 potassium acetate 、 sodium carbonate 作用下， 以 1,4-二氧六环 、 水 、 乙腈 为溶剂， 反应 29.0h， 生成 N-(2-chlorophenyl)-6-(pyridin-2-yl)imidazo[1,2-a]pyridine-3-carboxamide
  参考文献：
  名称：

  [EN] INHIBITORS OF EPHB3 SIGNALING
  [FR] INHIBITEURS DE LA SIGNALISATION DE EPHB3

  摘要：

  The present application provides EphB3 kinase inhibitors, useful in treating neurodegenerative or demyelinating diseases or conditions such as autoimmune encephalomyelitis and multiple sclerosis.

  公开号：

  WO2022187612A1
• 作为产物：
  描述：

  6-溴咪唑并[1,2-a]吡啶-3-羧酸 、 邻氯苯胺 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以78%的产率得到6-bromo-N-(2-chlorophenyl)imidazo[1,2-a]pyridine-3-carboxamide
  参考文献：
  名称：

  [EN] INHIBITORS OF EPHB3 SIGNALING
  [FR] INHIBITEURS DE LA SIGNALISATION DE EPHB3

  摘要：

  The present application provides EphB3 kinase inhibitors, useful in treating neurodegenerative or demyelinating diseases or conditions such as autoimmune encephalomyelitis and multiple sclerosis.

  公开号：

  WO2022187612A1

文献信息

• Inhibiting EPH B-3 Kinase
  申请人：Qiao Lixin

  公开号：US20120238597A1

  公开（公告）日：2012-09-20

  EphB3 kinase inhibitor compounds, including certain pyrazolo[1,5-a]pyridine and imidazo[1,2-a]pyridine compounds, inhibit EphB3 kinase. The EphB3 kinase inhibitor compounds can have greater potency for the inhibition of EphB3 kinase than general kinase inhibitors. Pharmaceutical compositions, such as neuroprotective agents, comprising the EphB3 kinase inhibitor compounds are also provided. The EphB3 kinase inhibitor compounds and pharmaceutical compositions are useful, for example, to provide neuroprotection and/or repair of neuronal tissue damaged during an ischemic event, such as a stroke.
• US8927545B2
  申请人：——

  公开号：US8927545B2

  公开（公告）日：2015-01-06
• [EN] INHIBITING EPH B-3 KINASE<br/>[FR] INHIBITION DE L'ENZYME EPHB3 KINASE
  申请人：BRIGHAM & WOMENS HOSPITAL

  公开号：WO2010117787A2

  公开（公告）日：2010-10-14

  EphB3 kinase inhibitor compounds, including certain pyrazolo[1,5-a]pyridine and imidazo[1,2-a]pyridine compounds, inhibit EphB3 kinase. The EphB3 kinase inhibitor compounds can have greater potency for the inhibition of EphB3 kinase than general kinase inhibitors. Pharmaceutical compositions, such as neuroprotective agents, comprising the EphB3 kinase inhibitor compounds are also provided. The EphB3 kinase inhibitor compounds and pharmaceutical compositions are useful, for example, to provide neuroprotection and/or repair of neuronal tissue damaged during an ischemic event, such as a stroke.