| 1089176-50-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• CAS: 1089176-50-0
• 化学式: C₂₃H₂₁N₃O₆S
• 分子量: 467.502
• InChiKey: DBYVGIHJADRRLI-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  以 N,N-二甲基甲酰胺 为溶剂， 以76%的产率得到
  参考文献：
  名称：

  Azines and azoles: CXXVI. First example of a novel heterocyclic system: Pyrimido[1,6-a][1,5]benzodiazepines

  摘要：

  4-Hydroxy-5-(2-R-2,3-dihydro-1H-1,5-benzodiazepin-4-yl)-2H-1,3-thiazine-2,6-diones readily undergo acylation at the N-1 atom of the benzodiazepine system by the action of acetic anhydride. Heating of the acetylated products in boiling dimethylformamide leads to the formation of 75-93% of the corresponding 7-acetyl-6-R-6,7-dihydropyrimido[1,6-a][1,5]benzodiazepine-1,3-diones that are derivatives of hitherto unknown fused heterocyclic system, pyrimido[1,6-a][1,5]benzodiazepine. 4-Hydroxy-5-(2-R-2,3-dihydro-1H1,5-benzodiazepin-4-yl)-2H-1,3-thiazine-2,6-diones are converted into 1-(2-aminophenyl)-6-(2-R-vinyl)uracils on heating in boiling DMF.

  DOI：

  10.1134/s1070363207120146
• 作为产物：
  描述：

  、 乙酸酐 反应 0.5h， 以85%的产率得到
  参考文献：
  名称：

  Azines and azoles: CXXVI. First example of a novel heterocyclic system: Pyrimido[1,6-a][1,5]benzodiazepines

  摘要：

  4-Hydroxy-5-(2-R-2,3-dihydro-1H-1,5-benzodiazepin-4-yl)-2H-1,3-thiazine-2,6-diones readily undergo acylation at the N-1 atom of the benzodiazepine system by the action of acetic anhydride. Heating of the acetylated products in boiling dimethylformamide leads to the formation of 75-93% of the corresponding 7-acetyl-6-R-6,7-dihydropyrimido[1,6-a][1,5]benzodiazepine-1,3-diones that are derivatives of hitherto unknown fused heterocyclic system, pyrimido[1,6-a][1,5]benzodiazepine. 4-Hydroxy-5-(2-R-2,3-dihydro-1H1,5-benzodiazepin-4-yl)-2H-1,3-thiazine-2,6-diones are converted into 1-(2-aminophenyl)-6-(2-R-vinyl)uracils on heating in boiling DMF.

  DOI：

  10.1134/s1070363207120146