3-(phenyltetrasulfanyl)propanoic acid | 1443749-96-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-(phenyltetrasulfanyl)propanoic acid
• CAS: 1443749-96-9
• 化学式: C₁₀H₁₂O₂S₄
• 分子量: 292.468
• InChiKey: QYNXEJGVTXNXSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.34
• 重原子数：
  16.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  苄硫醇 、 3-巯基丙酸 在 吡啶 、 二氯化二硫 作用下， 以 乙醚 为溶剂， 反应 2.0h， 以75%的产率得到3-(phenyltetrasulfanyl)propanoic acid
  参考文献：
  名称：

  Tetrasulfanes as Selective Modulators of the Cellular Thiolstat

  摘要：

  Naturally occurring polysulfanes often exhibit a wide spectrum of biological activity, which results from their ability to react with, and hence modify cysteine residues in key proteins and enzymes of the cellular thiolstat. Such interactions frequently proceed via S-thiolation of cysteine residues and subsequent formation of Reactive Oxygen Species. Polysulfanes are highly effective, yet also surprisingly selective for cysteine residues and enable the control of numerous cellular processes ranging from an activation of antioxidant defenses to the induction of programed cell death. Unfortunately, the arsenal of natural tri- and tetrasulfanes is limited. Here, we showcase the synthesis of asymmetric tetrasulfanes, which exhibit an interesting nematocidal activity and represent a new generation of tailor-made polysulfanes with potential applications in the field of agriculture and medicine. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus Sulfur and Silicon and the Related Elements.

  DOI：

  10.1080/10426507.2012.746691