{3-[4-(2,2-dimethyl-propionylamino)-2-(trifluoro-ethanesulfonylmethyl)-phenoxy]-4-methoxy-phenyl}-acetic acid | 1203503-74-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: {3-[4-(2,2-dimethyl-propionylamino)-2-(trifluoro-ethanesulfonylmethyl)-phenoxy]-4-methoxy-phenyl}-acetic acid
• 英文别名: 2-[3-[4-(2,2-Dimethylpropanoylamino)-2-(2,2,2-trifluoroethylsulfonylmethyl)phenoxy]-4-methoxyphenyl]acetic acid
• CAS: 1203503-74-5
• 化学式: C₂₃H₂₆F₃NO₇S
• 分子量: 517.523
• InChiKey: NDXBDDNNYODIHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
  申请人：HUTCHINSON John Howard

  公开号：US20100004331A1

  公开（公告）日：2010-01-07

  Described herein are compounds that are antagonists of PGD 2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD 2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD 2 -dependent or PGD 2 -mediated conditions or diseases.

  本文描述了一些作为PGD2受体拮抗剂的化合物。还描述了包括本文描述的化合物的药物组合物，以及使用这些PGD2受体拮抗剂的方法，单独或与其他化合物结合，用于治疗呼吸系统、心血管系统和其他依赖或介导于PGD2的疾病或病况。
• Antagonists of Prostaglandin D2 Receptors
  申请人：Hutchinson John Howard

  公开号：US20110190227A1

  公开（公告）日：2011-08-04

  Described herein are compounds that are antagonists of PGD 2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists Of PGD 2 receptors. Also described herein are methods of using such antagonists of PGD 2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD 2 -dependent or PGD 2 -mediated conditions or diseases.

  本文描述了一些PGD2受体拮抗剂化合物。还描述了包括这些化合物的药物组合物和药物，这些药物是PGD2受体拮抗剂。本文还描述了使用这些PGD2受体拮抗剂的方法，单独或与其他化合物结合，用于治疗呼吸系统、心血管系统和其他依赖于PGD2或通过PGD2介导的疾病或疾病的方法。
• US8071807B2
  申请人：——

  公开号：US8071807B2

  公开（公告）日：2011-12-06
• [EN] ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS<br/>[FR] ANTAGONISTES DES RÉCEPTEURS DE LA PROSTAGLANDINE D2
  申请人：AMIRA PHARMACEUTICALS INC

  公开号：WO2010003127A2

  公开（公告）日：2010-01-07

  Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists Of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.