(1S,3R,4S,5R,6S)-1-amino-3-(2,2-dimethylpent-4-enylamino)-7-oxaspiro[5.6]dodec-9-ene-4,5-diol | 1261084-77-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S,3R,4S,5R,6S)-1-amino-3-(2,2-dimethylpent-4-enylamino)-7-oxaspiro[5.6]dodec-9-ene-4,5-diol
• CAS: 1261084-77-8
• 化学式: C₁₈H₃₂N₂O₃
• 分子量: 324.464
• InChiKey: DMJPZNSQIMFJNQ-JFBPSJKJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  87.7
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 水 、 potassium hydroxide 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以78%的产率得到(1S,3R,4S,5R,6S)-1-amino-3-(2,2-dimethylpent-4-enylamino)-7-oxaspiro[5.6]dodec-9-ene-4,5-diol
  参考文献：
  名称：

  Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome

  摘要：

  Previous work from our group described the synthesis and biological evaluation of new rigid, 6,6- and 6,7-spiro aminoglycosidic scaffolds targeting the bacterial ribosome. Herein we describe an improved synthetic protocol for their construction, and extend our study by further amino-functionalization of their 6,7-spiro analogs. The synthetic strategy, preparation and evaluation of some representative examples are reported. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.10.001

文献信息

• Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome
  作者：Christos I. Stathakis、Ioannis Mavridis、Georgia Kythreoti、Athanasios Papakyriakou、Ioannis A. Katsoulis、Thomas Cottin、Panoula Anastasopoulou、Dionisios Vourloumis

  DOI：10.1016/j.bmcl.2010.10.001

  日期：2010.12

  Previous work from our group described the synthesis and biological evaluation of new rigid, 6,6- and 6,7-spiro aminoglycosidic scaffolds targeting the bacterial ribosome. Herein we describe an improved synthetic protocol for their construction, and extend our study by further amino-functionalization of their 6,7-spiro analogs. The synthetic strategy, preparation and evaluation of some representative examples are reported. (C) 2010 Elsevier Ltd. All rights reserved.