2-chloro-10-(5-cyclohexylpentyl)-5-methyl-10H-indolo[3,2-b]quinolin-5-ium iodide | 1268525-85-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-chloro-10-(5-cyclohexylpentyl)-5-methyl-10H-indolo[3,2-b]quinolin-5-ium iodide
• 英文别名: 2-Chloro-10-(5-cyclohexylpentyl)-5-methyl-indolo[3,2-b]quinolin-5-ium hydroiodide；2-chloro-10-(5-cyclohexylpentyl)-5-methylindolo[3,2-b]quinolin-5-ium;iodide
• CAS: 1268525-85-4
• 化学式: C₂₇H₃₂ClN₂*I
• 分子量: 546.922
• InChiKey: VAWPDTWEZDQTEW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.57
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  8.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  、 碘甲烷 以 甲苯 为溶剂， 反应 24.0h， 以72%的产率得到2-chloro-10-(5-cyclohexylpentyl)-5-methyl-10H-indolo[3,2-b]quinolin-5-ium iodide
  参考文献：
  名称：

  Identification of 3-phenylaminoquinolinium and 3-phenylaminopyridinium salts as new agents against opportunistic fungal pathogens

  摘要：

  Previous studies on the indoloquinoline alkaloid, cryptolepine (2), revealed that it has antii-nfective properties among other activities. Using Structure-activity relationship (SAR) techniques, several ring-opened analogs of cryptolepine (3-phenylaminopyridinium and 3-phenylaminoquinolinium derivatives) were designed to improve the potency and lower the cytotoxicity shown by several of the precursor agents. Results indicate that these ring-opened analogs constitute new anti-infective agents with over a 100-fold potency and several fold lower cytotoxicity than cryptolepine from which they are derived. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2010.10.065

文献信息

• Identification of 3-phenylaminoquinolinium and 3-phenylaminopyridinium salts as new agents against opportunistic fungal pathogens
  作者：Tryphon K. Mazu、Jagan R. Etukala、Xue Y. Zhu、Melissa R. Jacob、Shabana I. Khan、Larry A. Walker、Seth Y. Ablordeppey

  DOI：10.1016/j.bmc.2010.10.065

  日期：2011.1

  Previous studies on the indoloquinoline alkaloid, cryptolepine (2), revealed that it has antii-nfective properties among other activities. Using Structure-activity relationship (SAR) techniques, several ring-opened analogs of cryptolepine (3-phenylaminopyridinium and 3-phenylaminoquinolinium derivatives) were designed to improve the potency and lower the cytotoxicity shown by several of the precursor agents. Results indicate that these ring-opened analogs constitute new anti-infective agents with over a 100-fold potency and several fold lower cytotoxicity than cryptolepine from which they are derived. Published by Elsevier Ltd.