2-(nitrooxy)ethyl 8-(5-octyl-2-thioxo-2H-imidazol-4-yl)octanoate | 1269416-67-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(nitrooxy)ethyl 8-(5-octyl-2-thioxo-2H-imidazol-4-yl)octanoate
• 英文别名: 2-Nitrooxyethyl 8-(5-octyl-2-sulfanylideneimidazol-4-yl)octanoate
• CAS: 1269416-67-2
• 化学式: C₂₁H₃₅N₃O₅S
• 分子量: 441.592
• InChiKey: HRDGSOWSJLQQGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  30
• 可旋转键数：
  19
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  138
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-hydroxyethyl 8-(5-octyl-2-thioxo-2H-imidazol-4-yl)octanoate 在 硫酸 、 硝酸 作用下， 反应 1.0h， 生成 2-(nitrooxy)ethyl 8-(5-octyl-2-thioxo-2H-imidazol-4-yl)octanoate
  参考文献：
  名称：

  Antioxidant, anti-inflammatory and anti-hyperglycaemic activities of heterocyclic homoprostanoid derivatives

  摘要：

  A series of 19 heterocyclic homoprostanoids were synthesized from easily available oleic and ricinoleic acids and evaluated for their possible antioxidant, anti-inflammatory and anti-hyperlipidaemic activities. Compounds with thioxo- and oxoimidazole ring (1) and (2) have shown potent antioxidant activity with IC(50) values 0.23 +/- 0.09 and 0.41 +/- 0.01 mM comparable with standard ascorbic acid. Compound (3) with a quinoxaline ring showed maximum inhibition of BSA denaturation at 1 mM concentration and comparable with standard diclofenac. Incorporation of electron withdrawing substitutions like chloro- and nitro-groups in the quinoxaline ring has resulted in an increase anti-inflammatory activity. Test compounds (3), (3a) and (3c) showed modest inhibition of DPP-IV in vitro. However, the unsubstituted quinoxaline (3) and substituted quinoxalines (3b and 3c) reduced plasma glucose levels indicating the presence of hypoglycemic activity. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.11.016

文献信息

• Antioxidant, anti-inflammatory and anti-hyperglycaemic activities of heterocyclic homoprostanoid derivatives
  作者：S.A. Manohara Reddy、Jayesh Mudgal、Punit Bansal、S.G. Vasanthraju、K.K. Srinivasan、C. Mallikarjuna Rao、N. Gopalan Kutty

  DOI：10.1016/j.bmc.2010.11.016

  日期：2011.1

  A series of 19 heterocyclic homoprostanoids were synthesized from easily available oleic and ricinoleic acids and evaluated for their possible antioxidant, anti-inflammatory and anti-hyperlipidaemic activities. Compounds with thioxo- and oxoimidazole ring (1) and (2) have shown potent antioxidant activity with IC(50) values 0.23 +/- 0.09 and 0.41 +/- 0.01 mM comparable with standard ascorbic acid. Compound (3) with a quinoxaline ring showed maximum inhibition of BSA denaturation at 1 mM concentration and comparable with standard diclofenac. Incorporation of electron withdrawing substitutions like chloro- and nitro-groups in the quinoxaline ring has resulted in an increase anti-inflammatory activity. Test compounds (3), (3a) and (3c) showed modest inhibition of DPP-IV in vitro. However, the unsubstituted quinoxaline (3) and substituted quinoxalines (3b and 3c) reduced plasma glucose levels indicating the presence of hypoglycemic activity. (C) 2010 Elsevier Ltd. All rights reserved.