2-Isopropyl-5-methanesulfonyl-[1,3,4]oxadiazole | 163619-98-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Isopropyl-5-methanesulfonyl-[1,3,4]oxadiazole
• 英文别名: 2-(1-Methylethyl)-5-(methylsulfonyl)-1,3,4-oxadiazole；2-methylsulfonyl-5-propan-2-yl-1,3,4-oxadiazole
• CAS: 163619-98-5
• 化学式: C₆H₁₀N₂O₃S
• 分子量: 190.223
• InChiKey: YIZAFWOHJOFDES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  81.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Isopropyl-5-methanesulfonyl-[1,3,4]oxadiazole 在 sodium azide 作用下， 以 乙醇 为溶剂， 反应 0.17h， 以90%的产率得到2-Azido-5-isopropyl-[1,3,4]oxadiazole
  参考文献：
  名称：

  A novel synthesis of peptides based on the photochemistry of 5-azido-1,3,4-oxadiazoles

  摘要：

  DOI：

  10.1021/ja00342a044

文献信息

• Platinum compounds, compositions, and uses thereof
  申请人：PLACON THERAPEUTICS, INC.

  公开号：US10342801B2

  公开（公告）日：2019-07-09

  The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein.

  本教导涉及用于治疗癌症的化合物和组合物。在一些实施方案中，组合物包含铂（IV）络合物，该铂络合物具有至少一个反应基团，可与蛋白质上的官能团反应。
• PLATINUM COMPOUNDS, COMPOSITIONS, AND USES THEREOF
  申请人：BLEND THERAPEUTICS, INC.

  公开号：US20160068557A1

  公开（公告）日：2016-03-10

  The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein, engineered protein, antibody, antibody fragment, peptide, agonist, antagonist, aptamer or ligand which may be capable of recognizing a selected target cell population, and/or derivatives/analogs/mimics thereof.
• COMPOSITIONS AND METHODS FOR IMMUNO-ONCOLOGY THERAPIES
  申请人：TARVEDA THERAPEUTICS, INC.

  公开号：US20180221503A1

  公开（公告）日：2018-08-09

  The present invention relates to cancer immunotherapy. Conjugates and nanoparticles comprising active agents that can elicit a cancer specific immune response are provided. The conjugates comprise one or more targeting moieties that are connected to the active agents. Nanoparticles comprising the conjugates of the present invention are also provided to increase the delivery of the conjugates, and increase immunogenicity and lower toxicity.
• COMPOSITIONS AND METHODS FOR IMMUNOMODULATION
  申请人：TARVEDA THERAPEUTICS, INC.

  公开号：US20180221508A1

  公开（公告）日：2018-08-09

  The present invention relates to modulation of the tumor microenvironment to increase cancer specific immune responses. Conjugates, nanoparticles and formulations of the present invention relieve the inhibitory effect induced by tumor cells, and enhance antitumor immunity. The compostions provided herein can be used as immunotherapies, or as adjuvants used in conjunction with other immunotherapies such as peptide vaccines, cell vaccines and/or adoptive T cell transfer.
• US9403858B2
  申请人：——

  公开号：US9403858B2

  公开（公告）日：2016-08-02