2,4-Diaethoxy-5-methylpyridin | 50503-49-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,4-Diaethoxy-5-methylpyridin
• 英文别名: 2,4-diethoxy-5-methyl-pyridine；2,4-Diethoxy-5-methylpyridine
• CAS: 50503-49-6
• 化学式: C₁₀H₁₅NO₂
• 分子量: 181.235
• InChiKey: WPSBGGXIMQFNFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PROCESS FOR PRODUCTION OF 5-CHLORO-2,4-DIHYDROXYPYRIDINE
  申请人：Nagasawa Hiroshi

  公开号：US20090043101A1

  公开（公告）日：2009-02-12

  To provide an industrially advantageous process for producing 5-chloro-2,4-dihydroxypyridine, which is an inhibitor acting on a biodegradation enzyme that biodegrades an anti-malignant-tumor agent 5-fluorouracil. The process is carried out under mild conditions with a small number of steps and produces less industrial waste. The process employs a 5-chloro-1,3-dioxin-4-one derivative (2) as a starting substance to thereby form a pyrone derivative (4) represented by formula (4): (wherein R 3 and R 4 , which are identical to or different from each other, each represent a C1 to C6 linear-chain or branched-chain alkyl group, or a silyl group having a C1 to C6 linear-chain or branched-chain alkyl group), and subsequently, 5-chloro-2,4-dihydroxypyridine (1) is produced from the pyron derivative.

  提供一种在温和条件下，步骤少且产生较少工业废料的生产5-氯-2,4-二羟基吡啶的工业优势工艺。该工艺采用5-氯-1,3-二氧杂环戊-4-酮衍生物(2)作为起始物质，从而形成由式(4)表示的吡喃衍生物(4):(其中，R3和R4分别表示C1到C6的线性或支链烷基，或具有C1到C6的线性或支链烷基的硅基团，可以相同也可以不同)，随后从吡喃衍生物中产生5-氯-2,4-二羟基吡啶(1)。该化合物是一种抑制生物降解酶作用的抗恶性肿瘤药物5-氟尿嘧啶的抑制剂。
• US7557216B2
  申请人：——

  公开号：US7557216B2

  公开（公告）日：2009-07-07