1-[3-(1H-imidazol-4-yl)phenyl]ethan-1-one | 1897759-16-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[3-(1H-imidazol-4-yl)phenyl]ethan-1-one
• 英文别名: 1-[3-(1H-imidazol-5-yl)phenyl]ethanone
• CAS: 1897759-16-8
• 化学式: C₁₁H₁₀N₂O
• 分子量: 186.21
• InChiKey: PYLWRNSMASSFKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  45.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS
  申请人：Pfizer Inc.

  公开号：EP2947082A1

  公开（公告）日：2015-11-25

  The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.

  本发明提供了一种式 (I) 的化合物 或该化合物的药学上可接受的盐，其中 R1、R2、R3 和 R4 如本文所述；其药物组合物；及其在治疗通过抑制动物体内乙酰-CoA 羧化酶调节的疾病、病症或失调中的用途。
• [EN] N1-PYRAZOLOSPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS<br/>[FR] INHIBITEURS DE N1-PYRAZOLOSPIROCÉTONE ACÉTYL-COA CARBOXYLASE
  申请人：PFIZER

  公开号：WO2011058474A1

  公开（公告）日：2011-05-19

  The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl- CoA carboxylase enzyme(s) in an animal.