opt.-inakt. 1--propan-1,2,3-triol | 90201-79-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: opt.-inakt. 1--propan-1,2,3-triol
• 英文别名: 1-tetrahydropyran-2-yl-propane-1,2,3-triol；Tetrahydropyranyl glycerol；1-(oxan-2-yl)propane-1,2,3-triol
• CAS: 90201-79-9
• 化学式: C₈H₁₆O₄
• 分子量: 176.213
• InChiKey: DYVGSWYLZCBAMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• METHODS AND COMPOSITIONS FOR TARGETING AFAP
  申请人：West Virginia University C/o Office Of Technology

  公开号：EP2136620A2

  公开（公告）日：2009-12-30
• Methods and compositions for targeting AFAP
  申请人：Flynn Daniel C.

  公开号：US20080234232A1

  公开（公告）日：2008-09-25

  Embodiments of the invention are directed to methods and compositions for inhibiting activation of cSrc by human actin filament associated protein (AFAP). Libraries and methods of screening compositions for inhibitive activity are also provided. Also provided are methods of treating cancer. Cancer may be, for example, but is not limited to ovarian cancer, breast cancer, and gastrointestinal cancer. Also provided are methods of decreasing resistance to chemotherapy.
• [EN] METHODS AND COMPOSITIONS FOR TARGETING AFAP<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR CIBLER AFAP
  申请人：WEST VIRGINIA UNIVERSITY C O O

  公开号：WO2008133789A2

  公开（公告）日：2008-11-06

  (EN) Embodiments of the invention are directed to methods and compositions for inhibiting activation of cSrc by human actin filament associated protein (AFAP). Libraries and methods of screening compositions for inhibitive activity are also provided. Also provided are methods of treating cancer. Cancer may be, for example, but is not limited to ovarian cancer, breast cancer, and gastrointestinal cancer. Also provided are methods of decreasing resistance to chemotherapy.(FR) Les modes de réalisation de l'invention concernent des procédés et des compositions destinés à inhiber l'activation de cSrc par une protéine associée au filament de l'actine humaine (AFAP). L'invention concerne également des bibliothèques et procédés permettant de cribler des compositions pour une activité inhibitrice, ainsi que des procédés pour le traitement du cancer, par exemple le cancer de l'ovaire, le cancer du sein et le cancer gastro-intestinal. L'invention concerne enfin des procédés permettant de réduire la résistance à la chimiothérapie.