3-methyl-3-methylsulfanyl-butan-2-one | 39199-14-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methyl-3-methylsulfanyl-butan-2-one
• 英文别名: 3-Methyl-3-methylsulfanylbutan-2-one
• CAS: 39199-14-9
• 化学式: C₆H₁₂OS
• mdl: MFCD18813385
• 分子量: 132.227
• InChiKey: UZARABIVPQAQFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION
  申请人：Knoller Helmut

  公开号：US20130217871A1

  公开（公告）日：2013-08-22

  The present invention relates to hydroxyalkyl starch conjugates and a method for preparing the same, the hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one primary hydroxyl group, wherein the hydroxyalkyl starch is linked via said primary hydroxyl group to the cytotoxic agent. The conjugates according to the present invention have a structure according to the following formula HAS′(-L-M) n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold and a molar substitution (MS) in the range of from 0.6 to 1.5.

  本发明涉及羟基烷基淀粉共轭物及其制备方法，所述羟基烷基淀粉共轭物包括羟基烷基淀粉衍生物和细胞毒素药物，所述细胞毒素药物包括至少一个主要羟基基团，其中羟基烷基淀粉通过所述主要羟基基团与细胞毒素药物连接。本发明的共轭物具有以下式子的结构：HAS'(-L-M)n，其中M是细胞毒素药物的残基，L是连接基团，HAS'是羟基烷基淀粉衍生物的残基，n大于等于1，且羟基烷基淀粉衍生物具有平均分子量(MW)高于肾小球阈值且摩尔取代(MS)在0.6至1.5范围内。
• Hepatitis C Inhibitor Dipeptide Analogs
  申请人：BAILEY Murray D.

  公开号：US20090156822A1

  公开（公告）日：2009-06-18

  Compounds of formula (I): wherein R 1 , R 2 , R 3 , R 4 , n and m are as defined herein. The compounds are useful as inhibitors of HCV NS3 protease.

  式(I)的化合物：其中R1、R2、R3、R4、n和m的定义如本文所述。该化合物可用作HCV NS3蛋白酶的抑制剂。
• US7767818B2
  申请人：——

  公开号：US7767818B2

  公开（公告）日：2010-08-03