5-Chlor-2-ethyl-1,4-benzochinon | 38179-26-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Chlor-2-ethyl-1,4-benzochinon
• 英文别名: 2-Chloro-5-ethylcyclohexa-2,5-diene-1,4-dione
• CAS: 38179-26-9
• 化学式: C₈H₇ClO₂
• 分子量: 170.595
• InChiKey: AUUYXGCPTJIPEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Selective inhibition of Polo-like kinase 1
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP2065039A1

  公开（公告）日：2009-06-03

  The present invention relates to compounds having a 1,4-benzoquinone or 1,4-benzoquinone imine scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said 1,4-benzoquinone or 1,4-benzoquinone imine compounds can be used for prophylaxis and/or treatment of cancer and for prophylaxis and/or treatment of inflammatory diseases.

  本发明涉及具有1,4-苯醌或1,4-苯醌亚胺支架的化合物、这些化合物的药学上可接受的盐和含有至少一种这些化合物的药物组合物，以及药学上可接受的载体、赋形剂和/或稀释剂。所述 1,4-苯醌或 1,4-苯醌亚胺化合物可用于预防和/或治疗癌症以及预防和/或治疗炎症性疾病。
• [EN] SELECTIVE INHIBITION OF POLO-LIKE KINASE 1<br/>[FR] INHIBITION SÉLECTIVE DE LA POLO-LIKE KINASE 1
  申请人：MAX PLANCK GESELLSCHAFT

  公开号：WO2009068322A1

  公开（公告）日：2009-06-04

  The present invention relates to compounds having a 1,4-benzoquinone or 1,4- benzoquinone imine scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said 1,4- benzoquinone or 1,4-benzoquinone imine compounds can be used for prophylaxis and/or treatment of cancer and for prophylaxis and/or treatment of inflammatory diseases.