6-methylamino-hexan-2-ol | 118659-43-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-methylamino-hexan-2-ol
• 英文别名: 6-(Methylamino)hexan-2-ol
• CAS: 118659-43-1
• 化学式: C₇H₁₇NO
• mdl: MFCD19222403
• 分子量: 131.218
• InChiKey: WEUKLGGCEZLPOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-Oxo-hexansaeure-methylamid 在 lithium aluminium tetrahydride 、 乙醚 、 苯 作用下， 生成 6-methylamino-hexan-2-ol
  参考文献：
  名称：

  Lukes; Cerny, Collection of Czechoslovak Chemical Communications, 1959, vol. 24, p. 1287,1289

  摘要：

  DOI：

文献信息

• N-SUBSTITUTED ACYCLIC ETHYLENE DIAMINES
  申请人：Taminco bvba

  公开号：EP3290401A1

  公开（公告）日：2018-03-07

  Two alternative methods for producing at least one N-substituted acyclic ethylene diamine are provided: Method A according to the invention comprises: - reacting at least one reducing sugar, hydrogen and at least one primary amine NH2R or at least one secondary amine NHR'R" or a mixture of at least one primary amine NH2R and at least one secondary amine NHR'R" - in the presence of a supported hydrogenation catalyst - at a reaction temperature of 50°C to 200 °C, and - at a reaction pressure being superatmospheric pressure, and wherein - the molar ratio of the at least one primary amine and/or secondary amine : reducing sugar is at least 4:1. Method B according to the invention comprises the steps: 1. reacting at least one reducing sugar and at least one primary amine NH2R or at least one secondary amine NH2R'R" or a mixture of at least one primary amine NH2R and at least one secondary amine NHR'R" in a first step, and 2. reacting the reaction mixture obtained in step 1) with hydrogen in the presence of a supported hydrogenation catalyst in a second step.

  本发明提供了生产至少一种 N-取代无环乙二胺的两种替代方法： 根据本发明的方法 A 包括 - 使至少一种还原糖、氢和至少一种伯胺 NH2R 或至少一种仲胺 NHR'R" 或至少一种伯胺 NH2R 和至少一种仲胺 NHR'R" 的混合物反应 - 在支撑氢化催化剂存在下 - 反应温度为 50°C 至 200°C，以及 - 反应压力为超大气压，其中 - 至少一种伯胺和/或仲胺与还原糖的摩尔比至少为 4:1。 根据本发明的方法 B 包括以下步骤 在第一步中使至少一种还原糖和至少一种伯胺 NH2R 或至少一种仲胺 NH2R'R" 或至少一种伯胺 NH2R 和至少一种仲胺 NHR'R" 的混合物反应，以及 2. 在第二步中，将步骤 1) 中得到的反应混合物在有支撑氢化催化剂存在的情况下与氢气反应。
• REACTION OF GLYCOLALDEHYDE
  申请人：TAMINCO BVBA

  公开号：EP3774717A1

  公开（公告）日：2021-02-17
• REACTION OF GLYCOLADEHYDE
  申请人：Taminco BVBA

  公开号：US20210139410A1

  公开（公告）日：2021-05-13

  A two-step one-pot process for reacting glycolaldehyde with an aminating agent in the presence of a reactive organic fluid for instance a reactive solvent is provided. The first step comprises of contacting glycolaldehyde with an aminating agent in the presence of a reactive fluid for instance a reactive solvent under inert atmosphere to produce unsaturated intermediates, and reacting the reaction mixture obtained in step 1 with hydrogen in the presence of a supported hydrogenation catalyst in a second step.
• [EN] REACTION OF GLYCOLALDEHYDE<br/>[FR] RÉACTION DE GLYCOLALDÉHYDE
  申请人：UNIV LEUVEN KATH

  公开号：WO2019193117A1

  公开（公告）日：2019-10-10

  A two-step one-pot process for reacting glycolaldehyde with an aminating agent in the presence of a reactive organic fluid for instance a reactive solvent is provided. The first step comprises of contacting glycolaldehyde with an aminating agent in the presence of a reactive fluid for instance a reactive solvent under inert atmosphere to produce unsaturated intermediates, and reacting the reaction mixture obtained in step 1 with hydrogen in the presence of a supported hydrogenation catalyst in a second step.