SPH-1023 | 771457-62-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 石蒜科生物碱
• 英文名称: SPH-1023
• 英文别名: (1S,12S,14R)-9-methoxy-4-methyl-4-(2-pyrrolidin-1-ylethyl)-11-oxa-4-azoniatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol
• CAS: 771457-62-6
• 化学式: C₂₃H₃₃N₂O₃
• 分子量: 385.527
• InChiKey: NYAGWOIPYPJYKD-LXLGKWMXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHOD FOR THE PRODUCTION OF HIGH-PURITY 4A, 5, 9, 10, 11, 12,-HEXAHYDRO-6H-BENZOFURO [3A, 3, 2-EF] [2] BENZAZEPINE, AND THE DERIVATIVES THEREOF
  申请人：Welzig Stefan

  公开号：US20100105895A1

  公开（公告）日：2010-04-29

  A process for the production of extremely pure galanthamine or extremely pure galanthamine derivatives, whereby a start is made from racemic bromine narwedine, which is debrominated under palladium catalysis. The working-up of the reaction mixture, which is carried out in the presence of oxygen or peroxides, is essential to the process, so that the palladium catalyst is converted into an insoluble form, a form that can be easily separated. The further reaction is carried out by reduction of enantiomerically pure narwedine to form enantiomerically pure galanthamine, whereby it is then alkylated or dealkylated, so that a corresponding substitution on the ring-nitrogen atom is achieved. By further purification, such as recrystallization, residual portions of palladium of below 5 ppm are achieved, so that the direct use as a pharmaceutical raw material is made possible.

  一种生产极度纯净的迷迭香碱或极度纯净的迷迭香碱衍生物的方法，其中从外消旋溴纳尔维丁开始，经过钯催化脱溴化。在含氧气或过氧化物的存在下进行反应混合物的处理是该方法的关键，以便将钯催化剂转化为不溶性形式，易于分离。进一步的反应通过将外消旋纳尔维丁还原形成外消旋迷迭香碱，然后进行烷基化或去烷基化，从而在环氮原子上实现相应的取代。通过进一步的纯化，如再结晶，可以实现低于5 ppm的残留钯，从而使其直接用作制药原料成为可能。
• US8212029B2
  申请人：——

  公开号：US8212029B2

  公开（公告）日：2012-07-03