(+/-)9-[2-oxo-2-(3-bromo-phenyl)ethyl]-8-(4-piperidinyl)-2-(4-pyridinyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one | 1025556-97-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (+/-)9-[2-oxo-2-(3-bromo-phenyl)ethyl]-8-(4-piperidinyl)-2-(4-pyridinyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one
• 英文别名: 9-[2-(3-bromophenyl)-2-oxoethyl]-8-piperidin-4-yl-2-pyridin-4-yl-7,8-dihydro-6H-pyrimido[1,2-a]pyrimidin-4-one
• CAS: 1025556-97-1
• 化学式: C₂₅H₂₆BrN₅O₂
• 分子量: 508.418
• InChiKey: IANFGDJIRHTZDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  77.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• SUBSTITUTED 8-PIPERIDINYL-2-PYRIDINYL-PYRIMIDO[1,2-a] PYRIMIDIN-6-ONE AND 8-PIPERIDINYL-2-PYRIMIDINYL-PYRIMIDO[1,2-a] PYRIMIDIN-6-ONE DERIVATIVES
  申请人：LOCHEAD Alistair

  公开号：US20090281121A1

  公开（公告）日：2009-11-12

  The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof: Wherein X, Y, R1, R2, R3, R4, n, p, q, o and m are as described herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β, such as Alzheimer disease.

  本发明涉及一种由式(I)表示的嘧啶酮衍生物或其盐：其中，X、Y、R1、R2、R3、R4、n、p、q、o和m如本文所述。本发明还涉及一种药物，其包含所述衍生物或其盐作为活性成分，用于预防和/或治疗由GSK3β异常活性引起的神经退行性疾病，例如阿尔茨海默病。
• Subsitituted 8-piperidinyl-2-pyridinyl-pyrimido(1,2-a)pyrimidin-6-one and 8-piperidinyl-2-pyrimidinyl-pyrimido(1,2-a)pyrimidin-6-one derivatives
  申请人：Sanofi-Aventis

  公开号：EP1921080B1

  公开（公告）日：2009-08-05