8-methylnon-5-en-4-one | 1266679-43-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 8-methylnon-5-en-4-one
• CAS: 1266679-43-9
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: VFJLDYMHUWASHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.96
• 重原子数：
  11.0
• 可旋转键数：
  5.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  双苯磺酸甲烷 、 8-methylnon-5-en-4-one 在 奎宁胺 、 苯甲酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 96.0h， 以92%的产率得到R-6-(bis(phenylsulfonyl)methyl)-8-methylnonan-4-one
  参考文献：
  名称：

  α，β-不饱和酮与含磺酰基亲核试剂的催化不对称Michael反应：（R）-Muscone和（S）-芹菜酮的手性合成

  摘要：

  值得盐分的胺：手性伯胺盐催化的α，β-不饱和酮与含磺酰基的亲核试剂双（苯磺酰基）甲烷和1-（苯磺酰基）丙-2-酮的高度对映选择性迈克尔加成反应，已开发并具有出色的对映选择性（参见方案）。该方法已成功证明了其在（R）-麝香酮和（S）-芹菜酮的手性合成中的合成效用。

  DOI：

  10.1002/chem.201002418

文献信息

• ALDOLISATION-DEHYDRATION PROCESS
  申请人：DAVY McKEE (LONDON) LIMITED

  公开号：EP0634994A1

  公开（公告）日：1995-01-25
• [EN] COOLING SENSATION AGENT COMPOSITION AND SENSORY STIMULATION AGENT COMPOSITION<br/>[FR] COMPOSITION D'AGENT DE SENSATION DE FRAÎCHEUR ET COMPOSITION D'AGENT DE STIMULATION SENSORIELLE
  申请人：TAKASAGO PERFUMERY CO LTD

  公开号：WO2009123355A2

  公开（公告）日：2009-10-08

  The invention relates to a cooling sensation agent composition with a prolonged cool sensation effect comprising at least one compound selected from Formula (1) wherein each of A and B is a hydrogen atom or a hydrocarbon group which may have one or more substituents, in which A and B are not hydrogen atoms simultaneously, and the total number of carbon atoms in A and B is in the range of 6 to 18; and Formulae (2) to (4) wherein R1, R2, and R3 each represent a residue of an alcohol selected from l-menthol, l-isopulegol, 3-(l-menthoxy)propan-1,2-diol, 2-(l-menthoxy)ethan-1-ol, 3-(l-menthoxy)propan-1-ol, 2-methyl-3-(l-menthoxy)propan-1,2-diol and para-menthan-3,8-diol), and R4 represents a residue of a branched or straight-chain, cyclic or linear, or saturated or unsaturated alcohol having 6 to 18 carbon atoms that may have one or more aromatic rings that may have a condensed ring and substituent groups such as hydroxyl and ether groups; and R6 represents a hydrocarbon group having 11 to 19 carbon atoms that may be branched and contain one or more unsaturated bonds. The invention also relates to a sensory stimulation agent composition comprising the cooling sensation agent composition; a flavor or fragrance composition, a beverage or food product, a perfume or cosmetic product, a toiletry product, a daily utensil product or grocery, a fiber, a fiber product, a cloth or a medicine comprising the cooling sensation agent composition or the sensory stimulation agent composition; a production method thereof; a cooling processing method of a fiber, fiber product or a cloth, comprising compounding the cooling sensation agent composition or the sensory stimulation agent composition; and new compounds.