支链和直链的戊醇 | 94624-12-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 支链和直链的戊醇
• 英文名称: Pentanol-1 and 3-methylbutanol-1
• 英文别名: 3-methylbutan-1-ol;pentan-1-ol
• CAS: 94624-12-1
• 化学式: C10H24O2
• mdl: MFCD01075169
• 分子量: 176.3
• InChiKey: ZAZBXUDPQJLMIK-UHFFFAOYSA-N

物化性质

• 沸点：
  128-137℃
• 密度：
  0.815
• 闪点：
  45°(113°F)

计算性质

• 辛醇/水分配系数(LogP)：
  1.25
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 职业暴露等级：
  A
• 职业暴露限值：
  TWA: 100.0 ppm; 360.0 mg/m3, STEL: 125.0 ppm; 450.0 mg/m3
• 危险等级：
  3

文献信息

• Process for the preparation of n-butanol from ethanol and acetaldehyde
  申请人：Abengoa Bioenergía Nuevas Tecnologías, S. A.

  公开号：EP2889280A1

  公开（公告）日：2015-07-01

  The present invention generally relates to processes for preparation of higher alcohols such as n-butanol from lower alcohols such as ethanol by Guerbet condensation. In some aspects, the present invention relates to improvements in n-butanol yield and selectivity by the selection of process reaction conditions such as, but not limited to, mole ratio of hydrogen to ethanol, mole ratio of acetaldehyde to ethanol, mole ratio of ethyl acetate to ethanol and/or mole ratio of carbon monoxide to ethanol.

  本发明一般涉及通过Guerbet缩合从乙醇等低级醇制备高级醇如正丁醇的工艺。在某些方面，本发明涉及通过选择工艺反应条件（如氢与乙醇的摩尔比、乙醇与乙醛的摩尔比、乙醇与乙酸乙酯的摩尔比和/或乙醇与一氧化碳的摩尔比等）来改善正丁醇的产率和选择性。
• METHOD FOR OBTAINING HIGHER ALCOHOLS
  申请人：Abengoa Bionergía Nuevas Technologías, S. A.

  公开号：US20150166443A1

  公开（公告）日：2015-06-18

  The invention relates to a method for obtaining higher alcohols from lower alcohols with a catalyst that is a metal oxide comprising gallium and a noble metal selected from the list containing Pd, Pt, Ru, Rh and Re.

  本发明涉及一种利用催化剂从低级醇中获取高级醇的方法，该催化剂是由镓和从Pd，Pt，Ru，Rh和Re中选择的贵金属组成的金属氧化物。
• New Salts
  申请人：Ahlqvist Matti

  公开号：US20080269176A1

  公开（公告）日：2008-10-30

  There is provided pharmaceutically-acceptable acid addition salts of compounds of formula (I), wherein R 1 represents C 1-2 alkyl substituted by one or more fluoro substituents; R 2 represents C 1-2 alkyl; and n represents 0, 1 or 2, which salts are useful as prodrugs of competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required.

  提供了一种公式(I)化合物的药用酸加成盐，其中R1代表一种或多种氟代取代的C1-2烷基；R2代表C1-2烷基；n代表0、1或2。这些盐可用作竞争性蛋白酶抑制剂的前药，如凝血酶，因此特别适用于治疗需要抑制凝血酶的情况。
• Process for the preparation of higher alcohols from ethanol and N-hexanol by guerbet condensation
  申请人：Abengoa Bioenergia Nuevas Tecnologias, S.A.

  公开号：US10118880B2

  公开（公告）日：2018-11-06

  The present disclosure generally relates to processes for preparation of n-butanol, n-octanol and n-decanol from a reaction mixture comprising ethanoi and n-hexanol by Guerbet condensation. In some aspects, the present disclosure relates to improvements in n-octanol and n-decanol yield and selectivity by the selection of process reaction conditions such as, but not limited to, mole ratio of n-hexanol to ethanol. The present disclosure further generally relates to integrated processes for preparation of n-butanol in a n-butanol reactor from a reaction mixture comprising ethanol and hydrogen to produce a n-butanol product stream by Geurbet condensation comprising n-butanol and n-hexanol and for preparation of n-octanol in a n-octanol reactor from a reaction mixture comprising ethanol, n-hexanol and hydrogen to produce a n-octanol product stream by Geurbet condensation comprising n-butanol, n-hexanol and n-octanol. A predominant proportion of the n-hexanol contained in the n-butanol and n-octanol product streams is isolated and recycled to the n-octanol reaction mixture. In some aspects, the present disclosure relates to improvements in n-octanol and n-butanol yield and selectivity by the selection of process reaction conditions such as, but not limited to, mole ratio of n-hexanol to ethanol and recovery and recycle of n-hexanol.

  本公开一般涉及通过格尔伯特缩合法从由乙醇和正己醇组成的反应混合物中制备正丁醇、正辛醇和正癸醇的工艺。在某些方面，本公开涉及通过选择工艺反应条件（如但不限于正己醇与乙醇的摩尔比）来提高正辛醇和正癸醇的产率和选择性。本公开还一般涉及在正丁醇反应器中由乙醇和氢气组成的反应混合物制备正丁醇，通过由正丁醇和正己醇组成的Geurbet缩合生成正丁醇产品流的集成工艺，以及在正辛醇反应器中由乙醇、正己醇和氢气组成的反应混合物制备正辛醇，通过由正丁醇、正己醇和正辛醇组成的Geurbet缩合生成正辛醇产品流的集成工艺。正丁醇和正辛醇产物流中所含的大部分正己醇被分离出来并循环到正辛醇反应混合物中。在某些方面，本公开涉及通过选择工艺反应条件，例如但不限于正辛醇与乙醇的摩尔比以及正辛醇的回收和循环，来提高正辛醇和正丁醇的产率和选择性。
• Process for the preparation of higher alcohols from lower alcohols by Guerbet condensation
  申请人：Abengoa Bioenergia Nuevas Tecnologies, S.A.

  公开号：US10301241B2

  公开（公告）日：2019-05-28

  The present invention generally relates to processes for preparation of higher alcohols such as n-butanol from lower alcohols such as ethanol by Guerbet condensation. In some aspects, the present invention relates to improvements in n-butanol yield and selectivity by the selection of process reaction conditions such as, but not limited to, mole ratio of hydrogen to ethanol, mole ratio of acetaldehyde to ethanol, mole ratio of ethyl acetate to ethanol and/or mole ratio of carbon monoxide to ethanol.

  本发明一般涉及通过格尔伯特缩合法从低级醇（如乙醇）制备高级醇（如正丁醇）的工艺。在某些方面，本发明涉及通过选择工艺反应条件（如但不限于氢气与乙醇的摩尔比、乙醛与乙醇的摩尔比、乙酸乙酯与乙醇的摩尔比和/或一氧化碳与乙醇的摩尔比）来提高正丁醇的产率和选择性。