3-[4-(4-Pyridyloxy)benzenesulfonylamino]tetrahydrofuran-3-carboxylic acid hydroxyamide | 1348024-13-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[4-(4-Pyridyloxy)benzenesulfonylamino]tetrahydrofuran-3-carboxylic acid hydroxyamide
• 英文别名: N-hydroxy-3-[(4-pyridin-4-yloxyphenyl)sulfonylamino]oxolane-3-carboxamide
• CAS: 1348024-13-4
• 化学式: C₁₆H₁₇N₃O₆S
• 分子量: 379.393
• InChiKey: NBNLAYOCFMJGCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  135
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• 3-(ARYLSULFONYLAMINO)-TETRAHYDROFURAN-3-CARBOXYLIC ACID HYDROXAMIDES
  申请人：Pfizer Products Inc.

  公开号：EP1181285A2

  公开（公告）日：2002-02-27
• US6342521B1
  申请人：——

  公开号：US6342521B1

  公开（公告）日：2002-01-29
• [EN] 3-(ARYLSULFONYLAMINO)-TETRAHYDROFURAN-3-CARBOXYLIC ACID HYDROXAMIDES<br/>[FR] HYDROXAMIDES D'ACIDE 3-(ARYLSULFONYLAMINO)-TETRAHYDROFURANE-3-CARBOXYLIQUE
  申请人：PFIZER PROD INC

  公开号：WO2000073294A2

  公开（公告）日：2000-12-07

  A compound of formula (I) wherein R1, R2 and Q are as defined above, are useful in the treatment of an arthritis (including osteoarthritis and rheumatoid arthritis), cancer (such as solid tumor cancer including colon cancer, breast cancer, lung cancer and prostrate cancer and hematopoietic malignancies including leukemias and lymphomas), and other disorders. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID'S) and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.