((R)-4-{[3,5-difluoro-4-(4-fluoro-phenoxy)-benzenesulfonyl]-methyl-amino}-4,5,6,7-tetrahydro-indazol-1-yl)-acetic acid | 1204532-93-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ((R)-4-{[3,5-difluoro-4-(4-fluoro-phenoxy)-benzenesulfonyl]-methyl-amino}-4,5,6,7-tetrahydro-indazol-1-yl)-acetic acid
• 英文别名: 2-[(4R)-4-[[3,5-difluoro-4-(4-fluorophenoxy)phenyl]sulfonyl-methylamino]-4,5,6,7-tetrahydroindazol-1-yl]acetic acid
• CAS: 1204532-93-3
• 化学式: C₂₂H₂₀F₃N₃O₅S
• 分子量: 495.479
• InChiKey: GTAYUTWYKIQMDZ-LJQANCHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• AMINOTETRAHYDROINDAZOLOACETIC ACIDS
  申请人：Chen Li

  公开号：US20100016369A1

  公开（公告）日：2010-01-21

  The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R 1 -R 5 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

  这项发明涉及公式I的化合物： 以及其药学上可接受的盐和酯，其中Q、W、X、R1-R5和n在详细说明和权利要求中有定义。此外，本发明涉及制造和使用公式I化合物的方法，以及含有这些化合物的药物组合物。公式I的化合物是CRTH2受体的拮抗剂，可能在治疗与该受体相关的疾病和紊乱方面有用，如哮喘。
• Aminotetrahydroindazoloacetic Acids
  申请人：Chen Li

  公开号：US20120101131A1

  公开（公告）日：2012-04-26

  The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R 1 -R 5 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

  本发明涉及公式I的化合物：及其药学上可接受的盐和酯，其中Q、W、X、R1-R5和n在详细说明和权利要求中有定义。此外，本发明还涉及制造和使用公式I化合物的方法，以及含有这些化合物的药物组合物。公式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和障碍，如哮喘。
• US8138208B2
  申请人：——

  公开号：US8138208B2

  公开（公告）日：2012-03-20
• US8420675B2
  申请人：——

  公开号：US8420675B2

  公开（公告）日：2013-04-16