6-Methyl-2-phenyl-4-{(2R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-2H-pyridazin-3-one | 197301-92-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-Methyl-2-phenyl-4-{(2R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-2H-pyridazin-3-one
• CAS: 197301-92-1
• 化学式: C₄₁H₆₈N₂O₆
• 分子量: 685.001
• InChiKey: FRUHFWPLTIOIGV-YNLGSREGSA-N

反应信息

• 作为反应物：
  描述：

  (R)-(+)-α-甲氧基-α-(三氟甲基)苯乙酸 、 6-Methyl-2-phenyl-4-{(2R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-2H-pyridazin-3-one 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  Mono-tetrahydrofuran ring acetogenins from Goniothalamus donnaiensis

  摘要：

  A new type of annonaceous acetogenin was isolated from an ethanolic extract of the roots of Goniothalamus donnaiensis. The structures of two epimeric pairs, goniodonin and 34-epi-goniodonin, cis-goniodonin and 34-epi-cis-goniodonin, characterized by the presence of a gamma-hydroxymethyl-gamma-lactone moiety, were elucidated by spectral data and chemical derivatization. Two known mono-THF acetogenins, 2,4-cis- and trans-gigantetrocinone, were also found. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0031-9422(97)00116-7
• 作为产物：
  描述：

  苯肼 、 5-Hydroxy-5-methyl-3-{(2R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-5H-furan-2-one 以 乙醇 为溶剂， 反应 2.0h， 生成 6-Methyl-2-phenyl-4-{(2R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-5-((R)-1-hydroxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-2H-pyridazin-3-one
  参考文献：
  名称：

  Mono-tetrahydrofuran ring acetogenins from Goniothalamus donnaiensis

  摘要：

  A new type of annonaceous acetogenin was isolated from an ethanolic extract of the roots of Goniothalamus donnaiensis. The structures of two epimeric pairs, goniodonin and 34-epi-goniodonin, cis-goniodonin and 34-epi-cis-goniodonin, characterized by the presence of a gamma-hydroxymethyl-gamma-lactone moiety, were elucidated by spectral data and chemical derivatization. Two known mono-THF acetogenins, 2,4-cis- and trans-gigantetrocinone, were also found. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0031-9422(97)00116-7