1-(2-phosphonothio-4,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one | 286382-94-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-phosphonothio-4,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one
• 英文别名: [3,5-Dihydroxy-2-[3-(4-hydroxyphenyl)propanoyl]phenyl]sulfanylphosphonic acid
• CAS: 286382-94-3
• 化学式: C₁₅H₁₅O₇PS
• 分子量: 370.32
• InChiKey: DCVMGXYFUNHFSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  161
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Inhibition of intestinal apical membrane Na/phosphate co-transportation in humans
  申请人：——

  公开号：US20030162753A1

  公开（公告）日：2003-08-28

  The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate uptake in the intestines, or internally, where they interact with the phosphate control functions of the kidneys and parathyroid. They are useful for inhibiting sodium-mediated phosphate uptake, reducing serum PTH, calcium, calcitriol, and phosphate, and treating renal disease in an animal, including a human.

  化合物的化学式（I）为亲水性芳基磷酸酯、硫代磷酸酯和氨基磷酸酯，是肠道顶端膜Na介导的磷酸盐共同运输抑制剂。这些化合物可以经口服给药，在肠道中起到抑制Na依赖性磷酸盐摄取的作用，或者内部给药，在肾脏和甲状旁腺的磷酸盐控制功能中发挥作用。它们可用于抑制钠介导的磷酸盐摄取，降低血清PTH、钙、钙三醇和磷酸盐，治疗动物（包括人类）的肾脏疾病。
• Inhibitors of intestinal apical membrane Na/phosphate co-transportation
  申请人：——

  公开号：US20020133036A1

  公开（公告）日：2002-09-19

  The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate uptake in the intestines, or internally, where they interact with the phosphate control functions of the kidneys and parathyroid. They are therefore useful for inhibiting sodium-mediated phosphate uptake, reducing serum PTH, calcium, calcitriol, and phosphate, and treating renal disease in an animal, including a human.

  式（I）的化合物是亲水性芳基磷酸酯、硫代磷酸酯和氨基磷酸酯肠道顶端膜Na介导的磷酸共运输抑制剂。这些化合物可通过口服给药，在肠道内起到抑制依赖Na的磷酸摄取的作用，或在体内与肾脏和甲状旁腺的磷酸控制功能相互作用。因此，它们对于抑制钠介导的磷酸摄取、降低血清PTH、钙、活性维生素D和磷酸盐，以及治疗动物（包括人类）的肾脏疾病非常有用。
• INHIBITORS OF INTESTINAL APICAL MEMBRANE NA/PHOSPHATE CO-TRANSPORTATION
  申请人：BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM

  公开号：EP1175425A2

  公开（公告）日：2002-01-30
• US6355823B1
  申请人：——

  公开号：US6355823B1

  公开（公告）日：2002-03-12
• US6787528B2
  申请人：——

  公开号：US6787528B2

  公开（公告）日：2004-09-07