di-S-[5-acetamido-4-guanidino-3,4,5-trideoxy-D-glycero-α-D-galacto-non-2-enonic acid]pentaethylene glycol | 1538572-97-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: di-S-[5-acetamido-4-guanidino-3,4,5-trideoxy-D-glycero-α-D-galacto-non-2-enonic acid]pentaethylene glycol
• CAS: 1538572-97-2
• 化学式: C₃₄H₆₂N₈O₁₈S₂
• 分子量: 935.041
• InChiKey: JCQKVSSPIGOQAW-ZDDLRZDJSA-N

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 di-S-[5-acetamido-4-guanidino-3,4,5-trideoxy-D-glycero-α-D-galacto-non-2-enonic acid]pentaethylene glycol
  参考文献：
  名称：

  Bifunctional thiosialosides inhibit influenza virus

  摘要：

  We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.11.077