5-(2,4-difluorophenoxy)-3-(4-((1-(pyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-1,3,4-oxadiazol-2(3H)-one | 1233236-70-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(2,4-difluorophenoxy)-3-(4-((1-(pyrimidin-2-yl)piperidin-4-yl)methoxy)phenyl)-1,3,4-oxadiazol-2(3H)-one
• 英文别名: 5-(2,4-Difluorophenoxy)-3-[4-[(1-pyrimidin-2-ylpiperidin-4-yl)methoxy]phenyl]-1,3,4-oxadiazol-2-one
• CAS: 1233236-70-8
• 化学式: C₂₄H₂₁F₂N₅O₄
• 分子量: 481.459
• InChiKey: FMXRKFGNUNXNNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  89.4
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• [EN] 5-O-SUBSTITUTED 3-N-ARYL-1,3,4-OXADIAZOLONES FOR MEDICAL USE<br/>[FR] 3-N-ARYL-1,3,4-OXADIAZOLONES 5-O-SUBSTITUÉES DESTINÉES À UNE UTILISATION MÉDICALE
  申请人：BIAL PORTELA & CA SA

  公开号：WO2010074587A2

  公开（公告）日：2010-07-01

  The present invention relates to a compound of formula (I), wherein A represents an optionally substituted phenyl or a 5- or 6-membered heteroaromatic ring system containing up to 4 heteroatoms selected from O, S and N, B represents a single bond, O, S or NR1, wherein R1 is selected from hydrogen or a C1-C6-alkyl group; L represents a linker; C represents an amino moiety; n represents 0 or 1; m represents 0, 1, 2, 3, 4, 5 or 6; X represents O or S; and Y represents hydrogen or an optionally substituted carbon moiety; and to stereoisomers, pharmaceutically acceptable salts or esters, or prodrugs thereof. The compounds of the invention are potent FAAH inhibitors.