N-(2-(5-chloro-2-(2-fluoro-5-(1H-tetrazol-1-yl)phenylamino)pyrimidin-4-ylamino)-6-fluorophenyl)methanesulfonamide | 1251954-58-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(2-(5-chloro-2-(2-fluoro-5-(1H-tetrazol-1-yl)phenylamino)pyrimidin-4-ylamino)-6-fluorophenyl)methanesulfonamide
• 英文别名: N-[2-[[5-chloro-2-[2-fluoro-5-(tetrazol-1-yl)anilino]pyrimidin-4-yl]amino]-6-fluorophenyl]methanesulfonamide
• CAS: 1251954-58-1
• 化学式: C₁₈H₁₄ClF₂N₉O₂S
• 分子量: 493.884
• InChiKey: YJHMMXOJTFRSIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  148
• 氢给体数：
  3
• 氢受体数：
  12

文献信息

• FLUORO SUBSTITUTED PYRIMIDINE COMPOUNDS AS JAK3 INHIBITORS
  申请人：Harrison Richard John

  公开号：US20120040955A1

  公开（公告）日：2012-02-16

  The invention relates to compounds of formula (I) wherein AA, R 2 to R 7 and X 1 to X 3 have the meaning as cited in the description and the claims. Said compounds are useful as selective inhibitors of JAK3 over JAK2 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

  该发明涉及具有以下化学式（I）的化合物，其中AA，R2至R7和X1至X3的含义如描述和权利要求中所述。所述化合物可用作选择性JAK3抑制剂，用于治疗或预防免疫、炎症、自身免疫、过敏性疾病和免疫介导疾病。该发明还涉及包括所述化合物的药物组合物、该化合物的制备以及用作药物的用途。
• [EN] FLUORO SUBSTITUTED PYRIMIDINE COMPOUNDS AS JAK3 INHIBITORS<br/>[FR] COMPOSÉS DE PYRIMIDINE SUBSTITUÉS PAR FLUORO EN TANT QU'INHIBITEURS DE JAK3
  申请人：CELLZOME LTD

  公开号：WO2010118986A1

  公开（公告）日：2010-10-21

  The present invention relates to compounds of formula (I) wherein AA, R2 to R7 and X1 to X3 have the meaning as cited in the description and the claims. Said compounds are useful as selective inhibitors of JAK3 over JAK2 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.