1-(6-amino-purin-9-yl)-4-hydroxymethyl-α-L-threo-1-deoxy-pentofuranose | 55797-69-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 1-(6-amino-purin-9-yl)-4-hydroxymethyl-α-L-threo-1-deoxy-pentofuranose
• 英文别名: 9-[4-C-(hydroxymethyl)-beta-D-xylofuranosyl]adenine；(3R,4R,5R)-5-(6-aminopurin-9-yl)-2,2-bis(hydroxymethyl)oxolane-3,4-diol
• CAS: 55797-69-8
• 化学式: C₁₁H₁₅N₅O₅
• 分子量: 297.271
• InChiKey: WBNQTEKLVXXLQW-BRDIYROLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  160
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
  申请人：——

  公开号：US20040006007A1

  公开（公告）日：2004-01-08

  A compound, method and composition for treating a host infected with a hepatitis C viral comprising administering an effective hepatitis C treatment amount of a described 4′-disubstituted nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.

  提供一种用于治疗感染丙型肝炎病毒的宿主的化合物、方法和组合物，包括给予描述的4'-二取代核苷或其药用可接受的盐或前药的有效丙型肝炎治疗量。
• Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
  申请人：——

  公开号：US20040006002A1

  公开（公告）日：2004-01-08

  A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 4′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.

  提供一种用于治疗感染黄病毒或猪病毒的宿主的方法和组合物，包括给予所述的4'-修饰核苷或其药用可接受的盐或前药的有效黄病毒或猪病毒治疗剂量。
• Modified 2' and 3'-nucleoside prodrugs for treating flaviridae infections
  申请人：IDENIX Pharmaceuticals, Inc.

  公开号：EP2332952A1

  公开（公告）日：2011-06-15

  2' and/or 3' prodrugs of 1', 2', 3' or 4'-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.

  描述了 1'、2'、3'或 4'-溴核苷的 2'和/或 3'原药及其药学上可接受的盐和衍生物。这些原药可用于预防和治疗弗拉维病毒科感染（包括 HCV 感染）及其他相关疾病。描述了本发明原药的化合物和组合物。还提供了包括施用有效量的本发明原药或其药学上可接受的盐或衍生物的方法和用途。这些药物可选择与其他抗病毒药物联合或改变剂量使用，以预防或治疗弗拉维病毒科感染和其他相关疾病。
• Modified 2' and 3' -nucleoside prodrugs for treating flaviridae infections
  申请人：IDENIX Pharmaceuticals, Inc.

  公开号：EP2799442A1

  公开（公告）日：2014-11-05

  2' and/or 3' prodrugs of 1', 2', 3' or 4'-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.

  描述了 1'、2'、3'或 4'-溴核苷的 2'和/或 3'原药及其药学上可接受的盐和衍生物。这些原药可用于预防和治疗弗拉维病毒科感染（包括 HCV 感染）及其他相关疾病。描述了本发明原药的化合物和组合物。还提供了包括施用有效量的本发明原药或其药学上可接受的盐或衍生物的方法和用途。这些药物可选择与其他抗病毒药物联合或改变剂量使用，以预防或治疗弗拉维病毒科感染和其他相关疾病。
• METHODS AND COMPOSITIONS FOR TREATING HEPATITIS C VIRUS USING 4'-MODIFIED NUCLEOSIDES
  申请人：Idenix (Cayman) Limited

  公开号：EP1435974A2

  公开（公告）日：2004-07-14