4-Hydroxycyclohexylharnstoff | 22457-81-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Hydroxycyclohexylharnstoff
• 英文别名: (4-Hydroxycyclohexyl)urea
• CAS: 22457-81-4
• 化学式: C₇H₁₄N₂O₂
• mdl: MFCD12179633
• 分子量: 158.2
• InChiKey: XHGQUXWDFBTLKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• [EN] AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON<br/>[FR] COMPOSÉS D'AMINO-PYRIMIDINE EN TANT QU'INHIBITEURS DE TBKL ET OU D'IKK EPSILON
  申请人：MYREXIS INC

  公开号：WO2011046970A1

  公开（公告）日：2011-04-21

  The invention relates to certain amino-pyrimidine compounds which inhibit TBK1 and/or IKK epsilon and which may therefore find application in treating inflammation, cancer, septic shock and/or Primary open Angle Glaucoma (POAG).

  这项发明涉及抑制TBK1和/或IKK epsilon的某些氨基嘧啶化合物，因此可能在治疗炎症、癌症、感染性休克和/或原发性开角青光眼（POAG）中找到应用。
• [EN] 3-OXO-2,6-DIPHENYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES<br/>[FR] 3-OXO-2,6-DIPHÉNYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES
  申请人：BAYER PHARMA AG

  公开号：WO2017202816A1

  公开（公告）日：2017-11-30

  The present invention covers 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.

  本发明涵盖了一般式(I)的3-氧代-2,6-二苯基-2,3-二氢吡啶嗪-4-羧酰胺化合物：其中R1、R2、R3、R4、R5和R6如本文所定义，制备所述化合物的方法，用于制备所述化合物的有用中间体化合物，包括所述化合物的药物组合物和组合物，以及利用所述化合物制造用于治疗或预防疾病的药物组合物，特别是癌症或与异常AHR信号传导相关的疾病，或与10种不规则免疫反应或其他与异常AHR信号传导相关的疾病的情况，作为单一药剂或与其他活性成分结合使用。
• Process for the preparation of a segmented thermoplastic elastomer
  申请人：AKZO N.V.

  公开号：EP0013461A1

  公开（公告）日：1980-07-23

  A process for the preparation of a segmented thermoplastic elastomer, by conversion in a melt system of a. one or more-OH and/or-COOH groups- containing bifunctional polyesters or polyester amides having a melting point not higher than 100°C and a molecular weight in the range of 500 to 5000, and, b. one or more-OH and/or-COOH groups- containing bifunctional polyesters or polyester amides having a melting point not lower than 180°C and a molecular weight in the range of 500 to 5000 in the presence of such an amount of diisocyanate that the ratio between the number of -NCO groups and functional groups of both the low-melting and the high-melting compounds is at least 1,0 and at most 1,5, the transesterificafion catalyst present in one segment or in both being deactivated prior to the conversion process. The polymers resulting from the process may be heated for several hours at a temperature of 240°C without losing their elastomeric properties.

  一种制备分段热塑性弹性体的工艺，在熔融体系中通过以下物质的转化制备分段热塑性弹性体 a. 一种或多种含有 OH 和/或-COOH 基团的双官能团聚酯或聚酯酰胺，其熔点不高于 100°C，分子量在 500 至 5000 之间，以及 b. 含有一个或多个-OH 和/或-COOH 基团的双官能团聚酯或聚酯酰胺，其熔点不低于 180°C，分子量在 500 至 5000 之间，在有一定量的二异氰酸酯存在的情况下，低熔点化合物和高熔点化合物的-NCO 基团和官能团的数量之比至少为 1.0，最多为 1.5，在转化过程之前，存在于一个部分或两个部分中的酯化泡沫催化剂已失活。 该工艺产生的聚合物可在 240°C 的温度下加热数小时而不会失去其弹性特性。
• ANTIDEPRESSANT COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP3564253A1

  公开（公告）日：2019-11-06

  An antidepressant steroid compound and a preparation method and an application thereof; the structure of said compound is shown in formula (I), and the definition of each substituent is as described in the description and claims. Compound of the present invention may be used in the prevention, treatment, therapy or alleviation of a plurality of diseases and conditions such as depression.

  一种抗抑郁类固醇化合物及其制备方法和应用；所述化合物的结构如式（I）所示，各取代基的定义如说明书和权利要求书所述。本发明的化合物可用于预防、治疗、治疗或缓解多种疾病和病症，如抑郁症。
• EP1725238A4
  申请人：——

  公开号：EP1725238A4

  公开（公告）日：2009-04-01