Acetic acid 10-acetoxy-6,7-dioxo-6,6a,6b,7,12b,12c-hexahydro-5,8-dioxa-dibenzo[a,i]biphenylen-3-yl ester | 915222-37-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 3,4-二氢香豆素
• 英文名称: Acetic acid 10-acetoxy-6,7-dioxo-6,6a,6b,7,12b,12c-hexahydro-5,8-dioxa-dibenzo[a,i]biphenylen-3-yl ester
• 英文别名: (17-Acetyloxy-10,13-dioxo-9,14-dioxapentacyclo[10.8.0.02,11.03,8.015,20]icosa-3(8),4,6,15(20),16,18-hexaen-6-yl) acetate
• CAS: 915222-37-6
• 化学式: C₂₂H₁₆O₈
• 分子量: 408.364
• InChiKey: ZNWUFTNUCLCBQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Acetic acid 10-acetoxy-6,7-dioxo-6,6a,6b,7,12b,12c-hexahydro-5,8-dioxa-dibenzo[a,i]biphenylen-3-yl ester 以 乙腈 为溶剂， 反应 1.0h， 生成 7-乙酰氧基香豆素
  参考文献：
  名称：

  Optimisation of two-photon induced cleavage of molecular linker systems for drug delivery

  摘要：

  Photoreactive linker systems for drug delivery in modern ophthalmology are crucial for the efficiency of such applications. We compare 5 different linker molecule candidates (truxillic acid and 4 dimers of coumarin derivates) in solution regarding their chemical stability and two-photon induced cleavage efficiency, and shed light into the role of molecular structure in the cleavage reaction. Dimers of the coumarin family showed much higher two-photon induced cleavage efficiency, achieving the highest reaction cross-section when tert-Butyldimethylsilyl (TBS) was used as a substituent, being almost 5-times higher than the unsubstituted coumarin dimer. Coumarin-based linker systems react promptly with nucleophilic solvents, in particular with short chain alcohols. The polarity of such solvents which do not cause a lactone ring opening seems not to influence the cleavage of the cyclobutane ring in coumarin dimers. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jphotochem.2009.12.016
• 作为产物：
  描述：

  7-乙酰氧基香豆素 在 二苯甲酮 、 二氯甲烷 作用下， 以 氯仿 为溶剂， 反应 72.0h， 以50%的产率得到Acetic acid 10-acetoxy-6,7-dioxo-6,6a,6b,7,12b,12c-hexahydro-5,8-dioxa-dibenzo[a,i]biphenylen-3-yl ester
  参考文献：
  名称：

  Muthuramu, K.; Ramamurthy, V., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 6, p. 502 - 508

  摘要：

  DOI：

文献信息

• Acrylate coating compositions comprising a UV light cleavable cross-linking agent
  申请人：Monash University

  公开号：US11078368B2

  公开（公告）日：2021-08-03

  The present disclosure provides a coating composition for forming a coating that at least partially mobilizes in response to UV light, the composition comprising a monomer selected from acrylates, methacrylates and mixtures thereof, a cross-linking agent comprising two sub-units covalently bonded together, each sub-unit comprising an unsaturated group which is co-polymerisable with the monomer, wherein the two sub-units are adapted to dissociate in response to irradiation by UV light. The cross-linking agent may be present in the coating composition in an amount of less than 15 mol % of the total of the monomer and cross-linking agent.

  本公开提供了一种涂料组合物，用于形成在紫外线照射下至少部分移动的涂层，该组合物包括选自丙烯酸酯、甲基丙烯酸酯及其混合物的单体、交联剂，交联剂包括共价键合在一起的两个亚单元，每个亚单元包括可与单体共聚的不饱和基团，其中两个亚单元适于在紫外线照射下解离。交联剂在涂层组合物中的含量可低于单体和交联剂总量的 15 摩尔%。
• ACRYLATE COATING COMPOSITIONS COMPRISING A UV LIGHT CLEAVABLE CROSS-LINKING AGENT
  申请人：Monash University

  公开号：US20190071574A1

  公开（公告）日：2019-03-07

  The present disclosure provides a coating composition for forming a coating that at least partially mobilizes in response to UV light, the composition comprising a monomer selected from acrylates, methacrylates and mixtures thereof, a cross-linking agent comprising two sub-units covalently bonded together, each sub-unit comprising an unsaturated group which is co-polymerisable with the monomer, wherein the two sub-units are adapted to dissociate in response to irradiation by UV light. The cross-linking agent may be present in the coating composition in an amount of less than 15 mol % of the total of the monomer and cross-linking agent.