(1s,2r,5r)-Methyl 6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate | 943516-62-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1s,2r,5r)-Methyl 6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate
• 英文别名: methyl (1S,2R,5R)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate
• CAS: 943516-62-9
• 化学式: C₉H₁₅NO₂
• 分子量: 169.22
• InChiKey: KCIDWDVSBWPHLH-FSDSQADBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PROCESS FOR THE PREPARATION OF 6,6-DIMETHYL-3-AZABICYCLO-[3.1.0]- HEXANE COMPOUNDS UTILIZING BISULFITE INTERMEDIATE
  申请人：Berranger Thierry

  公开号：US20100145069A1

  公开（公告）日：2010-06-10

  The present invention provides for a process for preparing 6,6-Dimethyl-3-aza-bicyclo[3.1.0]hexane-2-sulfonate, an intermediateuseful in the efficient preparation of (1R,2S,5S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylic acid and esters and salts thereof, processes for preparing (1R,2S,5S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylic acid and esters and salts thereof from the sulfonate intermediate and processes for preparing 6,6-Dimethyl-3-aza-bicyclo[3.1.0]hexane-2-sulfonate.

  本发明提供了一种制备6,6-二甲基-3-氮杂双环[3.1.0]己烷-2-磺酸酯的方法，该方法是高效制备(1R,2S,5S)-甲基6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸及其酯和盐的中间体，以及从磺酸酯中间体制备(1R,2S,5S)-甲基6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸及其酯和盐的方法，以及制备6,6-二甲基-3-氮杂双环[3.1.0]己烷-2-磺酸酯的方法。
• BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS
  申请人：Mijts Benjamin

  公开号：US20100063300A1

  公开（公告）日：2010-03-11

  The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R 5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

  本披露提供了下列结构式的基本对映纯的杂双环化合物，其中A、M、M'和R5如本文所述，并提供了用于它们制备的生物催化过程以及在这些过程中使用的酶。
• Substantially Stereomerically Pure Fused Bicyclic Proline Compounds and Processes for Preparing Boceprevir
  申请人：Lalonde James

  公开号：US20120289709A1

  公开（公告）日：2012-11-15

  The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R 5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

  本公开提供以下结构式的基本对映纯的杂双环化合物，其中A、M、M'和R5如本文所述，并提供其生物催化制备的过程，以及用于该过程的酶。
• PROCESS FOR THE PREPARATION OF 6,6- DIMETHYL-3-AZABICYCLO-[3.1.0]-HEXANE COMPOUNDS AND ENANTIOMERIC SALTS THEREOF
  申请人：Wu George

  公开号：US20100256393A1

  公开（公告）日：2010-10-07

  The present invention provides for a process for preparing racemic methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate, its corresponding salt: (1R, 2S, 5S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-D-tartaric acid (“D-DTTA”) salt or a (1S, 2R, 5R)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-L-tartaric acid salt (“L-DTTA”) in a high enantiomeric excess. This invention also provides for a process for preparing a (1R, 2S, 5S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate dibenzoyl-D-tartaric acid (“D-DBTA”) salt or a (1S, 2R, 5R)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate L-tartaric acid (“L-DBTA”) salt in a high enantiomeric excess. Further, this invention provides a process for preparing intermediates II, IIB, III, IV, IV salt, V, VI, and VII.
• US8158807B2
  申请人：——

  公开号：US8158807B2

  公开（公告）日：2012-04-17