[2-nitro-5,10,15,20-tetrakis(3-methylphenyl)porphyrinato]copper(II) | 1116153-24-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: [2-nitro-5,10,15,20-tetrakis(3-methylphenyl)porphyrinato]copper(II)
• CAS: 1116153-24-2
• 化学式: C₄₈H₃₅CuN₅O₂
• 分子量: 777.384
• InChiKey: RSTFXJSLKHGYRN-YXXIKQBRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [2-nitro-5,10,15,20-tetrakis(3-methylphenyl)porphyrinato]copper(II) 在 硫酸 、 1,1,1-三甲基碘化肼 、 三氟乙酸 、 potassium hydroxide 作用下， 以 氯仿 、 二甲基亚砜 为溶剂， 反应 0.75h， 生成 2-amino-3-nitro-5,10,15,20-tetrakis(3-methylphenyl)porphyrin
  参考文献：
  名称：

  Direct β-amination reaction in porphyrin systems—a simple route to compounds containing two nitrogen substituents at both β-positions of the same pyrrole unit

  摘要：

  The direct beta-amination of porphyrin derivatives is described. 2-Nitro-meso-tetraarylporphyrins (zinc and copper complexes) react with N,N,N-trimethylhydrazinium iodide (TMHI) in the presence of a base (KOH/DMSO system, ca 70-80 degrees C) to give products of nucleophilic aromatic substitution of hydrogen. In this process, the nucleophilic replacement of a H-atom by an NH2 group takes place. The products obtained, bearing two neighbouring nitrogen substituents on the same pyrrole ring, are valuable intermediates for various synthetic uses. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.024
• 作为产物：
  描述：

  [5,10,15,20-tetrakis(3-methylphenyl)porphyrinato]copper(II) 在 硝酸 作用下， 以 氯仿 为溶剂， 以85%的产率得到[2-nitro-5,10,15,20-tetrakis(3-methylphenyl)porphyrinato]copper(II)
  参考文献：
  名称：

  Direct β-amination reaction in porphyrin systems—a simple route to compounds containing two nitrogen substituents at both β-positions of the same pyrrole unit

  摘要：

  The direct beta-amination of porphyrin derivatives is described. 2-Nitro-meso-tetraarylporphyrins (zinc and copper complexes) react with N,N,N-trimethylhydrazinium iodide (TMHI) in the presence of a base (KOH/DMSO system, ca 70-80 degrees C) to give products of nucleophilic aromatic substitution of hydrogen. In this process, the nucleophilic replacement of a H-atom by an NH2 group takes place. The products obtained, bearing two neighbouring nitrogen substituents on the same pyrrole ring, are valuable intermediates for various synthetic uses. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.024