5'-O-Carboxymethylguanosin | 27999-63-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 5'-O-Carboxymethylguanosin
• 英文别名: guanosin-5'-yloxy-acetic acid；2-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]acetic acid
• CAS: 27999-63-9
• 化学式: C₁₂H₁₅N₅O₇
• 分子量: 341.28
• InChiKey: SEIPWPNANMWCLV-TZQXKBMNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  182
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Pharmaceutical Composition Comprising a Mixture of Carboxylated Oligonucleotides
  申请人：Martynov Artur

  公开号：US20140309276A1

  公开（公告）日：2014-10-16

  The invention describes a pharmaceutical composition, comprising a mixture of carboxylated oligonucleotides, obtained by hydrolysis of natural polynucleotides, that results in oligonucleotide mixture, and carboxylation of purine nucleotide bases in the oligonucleotide mixture. The oligonucleotide mixture (DNA, RNA, or a combination of the two) of plant, animal, or fungal origin is conducted through chemical or biochemical enzymatic procedures, and then, a chemical modification of the oligonucleotides is provided, with carboxylation of their purine nucleotide bases through alkylation with monochloroacetic acid, or acylation with succinic anhydride. The pharmaceutical composition may be used in humans and animals for cancer treatment, immunodeficiency, viral infection diseases, etc.