4-Cyclopropyl-7-fluoro-5-methyl-6-pyrazin-2-ylpyrido[1,2-c]pyrimidine-1,3-dione | 477703-21-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并[1，2-a]吡嗪-8-酮
• 英文名称: 4-Cyclopropyl-7-fluoro-5-methyl-6-pyrazin-2-ylpyrido[1,2-c]pyrimidine-1,3-dione
• CAS: 477703-21-2
• 化学式: C₁₆H₁₃FN₄O₂
• 分子量: 312.303
• InChiKey: LEALLBUJKLQKCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  75.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Antibacterial agents
  申请人：——

  公开号：US20030114458A1

  公开（公告）日：2003-06-19

  The present invention provides compounds of Formula (I): 1 wherein R 1 -R 6 and K have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful as antibacterial agents. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, processes for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.

  本发明提供了化合物的公式（I）：其中R1-R6和K具有规范中定义的任何值，以及其药用盐，这些化合物可用作抗菌剂。还公开了包含一个或多个公式I化合物的药物组合物，用于制备公式I化合物的方法，以及用于制备公式I化合物的中间体。
• ANTIBACTERIAL AGENTS
  申请人：Warner-Lambert Company LLC

  公开号：EP1395585A1

  公开（公告）日：2004-03-10
• US6864259B2
  申请人：——

  公开号：US6864259B2

  公开（公告）日：2005-03-08
• [EN] ANTIBACTERIAL AGENTS<br/>[FR] AGENTS ANTIBACTERIENS
  申请人：WARNER LAMBERT CO

  公开号：WO2002096908A1

  公开（公告）日：2002-12-05

  The present invention provides compounds of Formula (I): wherein R1-R6 and K have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful as antibacterial agents. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, process for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.