The Preparation and Characterization of Nineteen New Phthalidyl Spirohydantoins
摘要:
Nineteen new N,N'-disubstituted phthalidyl spirohydantoins (6a-s) were prepared for the purpose of pharmacological testing. Their structure was deduced from the IR, H-1-NMR, C-13-NMR, mass spectra and elemental analysis. The two possible structural isomers - only one of which is formed - can be distinguished unequivocally on the basis of selective diastercotopicity of the alpha-methylene hydrogens adjacent to N-3' of the hydantoin ring.
The Preparation and Characterization of Nineteen New Phthalidyl Spirohydantoins
摘要:
Nineteen new N,N'-disubstituted phthalidyl spirohydantoins (6a-s) were prepared for the purpose of pharmacological testing. Their structure was deduced from the IR, H-1-NMR, C-13-NMR, mass spectra and elemental analysis. The two possible structural isomers - only one of which is formed - can be distinguished unequivocally on the basis of selective diastercotopicity of the alpha-methylene hydrogens adjacent to N-3' of the hydantoin ring.