3-(3-methylbut-2-enyl)-2-[2-(trimethylsilanyl)ethylsulfanyl]thiobenzoic acid S-[2-(trimethylsilanyl)ethyl]ester | 1035808-32-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3-methylbut-2-enyl)-2-[2-(trimethylsilanyl)ethylsulfanyl]thiobenzoic acid S-[2-(trimethylsilanyl)ethyl]ester
• 英文别名: S-(2-trimethylsilylethyl) 3-(3-methylbut-2-enyl)-2-(2-trimethylsilylethylsulfanyl)benzenecarbothioate
• CAS: 1035808-32-2
• 化学式: C₂₂H₃₈OS₂Si₂
• 分子量: 438.846
• InChiKey: BCOFSKSNFMHBFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.84
• 重原子数：
  27.0
• 可旋转键数：
  10.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  3-(3-methylbut-2-enyl)-2-[2-(trimethylsilanyl)ethylsulfanyl]thiobenzoic acid S-[2-(trimethylsilanyl)ethyl]ester 在 sodium phosphate buffer 、 3 A molecular sieve 、 四丁基氟化铵 、 二甲基二环氧乙烷 、 2-巯基乙醇 作用下， 以 四氢呋喃 、 丙酮 、 乙腈 为溶剂， 反应 6.0h， 生成 2-(1-hydroxy-1-methylethyl)-2,3-dihydrobenzo[b]thiophene-7-carboxylic acid methyl ester
  参考文献：
  名称：

  Small Molecules That Mimic the Thiol-Triggered Alkylating Properties Seen in the Natural Product Leinamycin

  摘要：

  Reaction of the antitumor agent leinamycin with cellular thiols results in conversion of the natural product to a DNA-alkylating episulfonium alkylating agent via an intriguing sequence of chemical reactions. To establish whether the chemistry first seen in leinamycin represents a general motif that can function in various molecular frameworks, construction of greatly simplified analogues containing only the "core" funcional groups anticipated to be necessary for thiol-triggered generation of an alkylating agent was undertaken. For this purpose, the "stripped-down" leinamycin analogue 7-(3-methyl-but-2-enyl)-1-oxo-1H-lambda4-benzo[1,2]dithiol-3-one (4) was synthesized. Treatment of 4 with thiol under several different conditions results in efficient conversion of the compound to cyclized 2,3-dihydro-benzo[b]thiophene-7-carboxylic acid products (13) that are envisioned to arise from Markovnikov addition of solvent to an intermediate episulfonium ion (14). Thus, the relatively simple molecule 4 is able to mimic the thiol-triggered alkylating properties displayed by the natural product leinamycin. This work helps define why the core functional groups required thiol-accelerated generation of an alkylating intermediate from leinamycin and indicates that substantially altered analogues of the natural product may retain alkylating properties. In a broader context, the results provide evidence that the unique cascade of chemical reactions first seen in the context of leinamycin represents a general motif that can operate in a variety of molecular frameworks.

  DOI：

  10.1021/ja029169y
• 作为产物：
  描述：

  {2-[2-bromo-6-(3-methylbut-2-enyl)phenylsulfanyl]ethyl}trimethylsilane 在 正丁基锂 、 草酰氯 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 、 正己烷 、 氯仿 、 苯 为溶剂， 反应 2.25h， 生成 3-(3-methylbut-2-enyl)-2-[2-(trimethylsilanyl)ethylsulfanyl]thiobenzoic acid S-[2-(trimethylsilanyl)ethyl]ester
  参考文献：
  名称：

  Small Molecules That Mimic the Thiol-Triggered Alkylating Properties Seen in the Natural Product Leinamycin

  摘要：

  Reaction of the antitumor agent leinamycin with cellular thiols results in conversion of the natural product to a DNA-alkylating episulfonium alkylating agent via an intriguing sequence of chemical reactions. To establish whether the chemistry first seen in leinamycin represents a general motif that can function in various molecular frameworks, construction of greatly simplified analogues containing only the "core" funcional groups anticipated to be necessary for thiol-triggered generation of an alkylating agent was undertaken. For this purpose, the "stripped-down" leinamycin analogue 7-(3-methyl-but-2-enyl)-1-oxo-1H-lambda4-benzo[1,2]dithiol-3-one (4) was synthesized. Treatment of 4 with thiol under several different conditions results in efficient conversion of the compound to cyclized 2,3-dihydro-benzo[b]thiophene-7-carboxylic acid products (13) that are envisioned to arise from Markovnikov addition of solvent to an intermediate episulfonium ion (14). Thus, the relatively simple molecule 4 is able to mimic the thiol-triggered alkylating properties displayed by the natural product leinamycin. This work helps define why the core functional groups required thiol-accelerated generation of an alkylating intermediate from leinamycin and indicates that substantially altered analogues of the natural product may retain alkylating properties. In a broader context, the results provide evidence that the unique cascade of chemical reactions first seen in the context of leinamycin represents a general motif that can operate in a variety of molecular frameworks.

  DOI：

  10.1021/ja029169y