Gd(10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclodecane-1,4,7-triacetate)(water) | 157072-96-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: Gd(10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclodecane-1,4,7-triacetate)(water)
• 英文别名: Gd(1,4,7-tris(carboxymethyl)-10-(2'-hydroxypropyl)-1,4,7,10-tetraazacyclododecane)(H2O)；Gd(HP-DO3A)(H2O)
• CAS: 157072-96-3
• 化学式: C₁₇H₃₁GdN₄O₈
• 分子量: 576.705
• InChiKey: TXSPCECQMBKDKY-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  gadolinium(III) oxide 、 10-(2-羟基丙基)-1,4,7,10-四氮杂环十二烷-1,4,7-三乙酸 以 水 为溶剂， 以56%的产率得到Gd(10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclodecane-1,4,7-triacetate)(water)
  参考文献：
  名称：

  Dischino; Delaney; Emswiler, Inorganic Chemistry, 1991, vol. 30, # 6, p. 1265 - 1269

  摘要：

  DOI：

文献信息

• Design and testing of paramagnetic liposome-based CEST agents for MRI visualization of payload release on pH-induced and ultrasound stimulation
  作者：Daniela Delli Castelli、Cinzia Boffa、Pierangela Giustetto、Enzo Terreno、Silvio Aime

  DOI：10.1007/s00775-013-1042-0

  日期：2014.2

  The development of nanomedicines in cancer therapy is constantly growing because of the advantages associated with the use of nanosized drug delivery systems. Among them, the possibility of accurate spatiotemporal control of the release of the chemotherapeutic from the carrier is one of the most interesting and clinically relevant. To further improve the therapy outcome, the clinical translation of imaging protocols for the in vivo visualization of the release step is of paramount importance. In this work, the combination of the great chemical versatility of liposomes and the outstanding potential of MRI chemical exchange saturation transfer agents has been successfully harnessed to image the selective release of the liposomal content stimulated by endogenous (variation of pH) and externally applied (nonfocused ultrasound) stimuli. The use of clinically safe components (both liposomes and MRI agents) and the good results obtained in vitro hold promise for a successful future in vivo translation.