| 1003274-79-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1003274-79-0
• 化学式: C₁₅H₂₂O₃
• 分子量: 250.338
• InChiKey: RXIBSGALOVAWTP-PWRGDLIESA-N

反应信息

• 作为产物：
  描述：

  在 二苯甲醇 、 三甲基铝 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 以68%的产率得到
  参考文献：
  名称：

  A Two-Directional Approach to a (−)-Dictyostatin C11−C23 Segment:  Development of a Highly Diastereoselective, Kinetically-Controlled Meerwein−Ponndorf−Verley Reduction

  摘要：

  A three-step synthesis of a precursor to the C11-C23 segment of (-)-dictyostatin is described. The sequence features a sonication-assisted, enantioselective double hetero Diels-Alder (HDA) reaction catalyzed by Jacobsen's Cr(III) Schiff base catalyst, followed by a novel, highly diastereoselective Meerwein-Ponndorf-Verley (MPV) reduction of the hydropyranone subunits under kinetic control to yield the bis(axial alcohol) 4. Generalized studies of both the HDA and MPV methodologies are also described.

  DOI：

  10.1021/ja077336u