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喹啉
水杨醛
二溴甲烷
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联苯烯

ethyl 5-amino-3-(2-fluorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate | 1105198-70-6

分子结构分类

有机化合物 - 有机杂环化合物 - 噻吩哒嗪类

中文名称

——

中文别名

——

英文名称

ethyl 5-amino-3-(2-fluorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate

英文别名

Ethyl 5-amino-3-(2-fluorophenyl)-4-oxothieno[3,4-d]pyridazine-1-carboxylate

ethyl 5-amino-3-(2-fluorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate化学式

CAS

1105198-70-6

化学式

C₁₅H₁₂FN₃O₃S

mdl

——

分子量

333.343

InChiKey

MOITYUTYYMHCAA-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

3.1
重原子数：

23
可旋转键数：

4
环数：

3.0
sp3杂化的碳原子比例：

0.13
拓扑面积：

113
氢给体数：

1
氢受体数：

7

文献信息

AMINOTHIENOPYRIDAZINE INHIBITORS OF TAU ASSEMBLY

申请人：Ballatore Carlo

公开号：US20130029983A1

公开（公告）日：2013-01-31

The present invention is directed to methods of inhibiting a tauopathy in a patient by administration of a compound of formula I: Novel aminothienopyridazine compounds are also described.

本发明涉及通过给予I型化合物来抑制患者的tau病变的方法：还描述了新的氨基噻吩吡嗪化合物。
[EN] AMINOTHIENOPYRIDAZINE INHIBITORS OF TAU ASSEMBLY<br/>[FR] INHIBITEURS AMINOTHIÉNOPYRIDAZINIQUES DE L'ASSEMBLAGE DES MICROTUBULES SOUS L'EFFET DE LA PROTÉINE TAU

申请人：UNIV PENNSYLVANIA

公开号：WO2011037985A1

公开（公告）日：2011-03-31

The present invention is directed to methods of inhibiting a tauopathy in a patient by administration of a compound of formula (I): Novel aminothienopyridazine compounds are also described.

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同类化合物

噻吩并[3,4-d]哒嗪-1-羧酸,5-氨基-3,4-二氢-3-(4-甲基苯基)-4-羰基-,乙基酯 1,4-二氯噻吩并[3,4-d]哒嗪 5-{2-[(E)-3-Methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-ylimino]-acetylamino}-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester 5-Amino-6-[5-[4-amino-1-(4-chlorophenyl)-5-cyano-6-iminopyridazine-3-carbonyl]-3,4-dimethylthieno[2,3-b]thiophene-2-carbonyl]-2-(4-chlorophenyl)-3-iminopyridazine-4-carbonitrile 3-cyano-2-(3-cyano-7,8-dioxo-6-phenyl-pyridazo[4,5-d]pyridazin-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene ethyl 5-amino-3-(2-fluorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate 7-amino-5-(4-methylphenyl)thieno[2,3-d]pyridazin-4(5H)-one ethyl 5-amino-3-(4-aminophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate 7-amino-5-(4-chlorophenyl)thieno[2,3-d]pyridazin-4(5H)-one 7-amino-5-(4-fluorophenyl)thieno[2,3-d]pyridazin-4(5H)-one 5-(4-chlorophenyl)-4-oxo-4,5-dihydrothieno[2,3-d]pyridazine-7-carbonyl azide 5,7-dichloro-2,3-dihydrothieno[3,4-d]pyridazine-1,4-dione 4-oxo-5-phenyl-4,5-dihydrothieno[2,3-d]pyridazine-7-carbonyl azide 5-methyl-4-oxo-4,5-dihydrothieno[2,3-d]pyridazine-7-carbonyl azide methyl 5-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[2,3-d]pyridazin-7-ylcarbamate 5-(4-methoxyphenyl)-4-oxo-4,5-dihydrothieno[2,3-d]pyridazine-7-carbonyl azide methyl 4-oxo-5-phenyl-4,5-dihydrothieno[2,3-d]pyridazin-7-ylcarbamate 5-(4-methylphenyl)-4-oxo-4,5-dihydrothieno[2,3-d]pyridazine-7-carbonyl azide 5-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[2,3-d]pyridazine-7-carbonyl azide ethyl 5-amino-4-oxo-3-(m-tolyl)-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate N-benzylidene 5-amino-3,4-dihydro-3-p-tolylthieno<3,4-d>pyridazin-1-hydrazide 7-amino-2-(4-chloro-phenyl)-5-methyl-2H-thieno[3,4-d]pyridazin-1-one ethyl 5-amino-3-(4-(dimethylamino)phenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate ethyl 5-amino-3-(4-(methylamino)phenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate ethyl 5-amino-3-(2-bromophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate 5-amino-3-(4-chlorophenyl)-N-(2-hydroxyethyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxamide ethyl 5-amino-3-(3-bromophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate ethyl 5-[(4,4-dimethyl-2,6-dioxocyclohexylidenemethyl)amino]-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate 5,7-Dimethyl-thieno<3,4-d>pyridazin ethyl 5-amino-3-(4-bromophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate ethyl 3-(3-chlorophenyl)-5-(N-methylacetamido)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate ethyl 5-amino-4-oxo-3-(4-(trifluoromethoxy)phenyl)-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate 5-amino-N-isopropyl-4-oxo-3-(4-(trifluoromethoxy)-phenyl)-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxamide 5-amino-4-oxo-3-(4-(trifluoromethoxy)phenyl)-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylic acid 5-amino-3-(4-chlorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carbohydrazide ethyl 5-amino-3-(2-chlorophenyl)-4-oxo-3,4-dihydrothieno-[3,4-d]pyridazine-1-carboxylate 7-amino-2-(4-chlorophenyl)-4-methylthieno[3,4-d]pyridazin-1(2H)-one 7-amino-4-methylthieno[3,4-d]pyridazin-1(2H)-one ethyl 5-amino-3-(4-fluorophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate 7-amino-4-methyl-2-(pyridin-3-yl)thieno[3,4-d]pyridazin-1(2H)-one 7-amino-2-benzyl-4-methylthieno[3,4-d]pyridazin-1(2H)-one 7-amino-4-methyl-2-(2,2,2-trifluoroethyl)thieno[3,4-d]pyridazin-1(2H)-one 7-amino-4-methyl-2-(pyridin-2-yl)thieno[3,4-d]pyridazin-1(2H)-one N,N-dimethyl-N'-(7-methyl-4-oxo-3-p-tolyl-1-p-tolylazo-3,4-dihydrothieno[3,4-d]pyridazin-5-yl)-formamidine ethyl 5-amino-4-oxo-3-(o-tolyl)-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate 7-amino-2-isopropyl-4-methylthieno[3,4-d]pyridazin-1(2H)-one ethyl 5-amino-4-oxo-3-(4-(trifluoromethylsulfonyloxy)phenyl)-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate ethyl 5-amino-3-(4-bromophenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate 5-amino-3-(4-chlorophenyl)-N-methyl-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxamide

相关结构分类

有机杂环化合物苯类化合物木脂素、新木脂素和相关化合物苯丙烷和聚酮脂质和类脂质分子有机酸及其衍生物有机氧化合物生物碱及其衍生物有机硫化合物核苷、核苷酸和类似物碳氢化合物衍生物有机氮化合物碳氢化合物有机卤素化合物有机聚合物有机金属化合物乙炔化物有机磷化合物叠烯有机1,3-偶极化合物碳化物有机盐有机阳离子卡宾有机阴离子

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