4-fluoro-2-[3-fluoro-5-(pyridin-3-yloxy)phenyl]-1H-13(2H)-dione | 1245607-33-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-fluoro-2-[3-fluoro-5-(pyridin-3-yloxy)phenyl]-1H-13(2H)-dione
• 英文别名: 4-fluoro-2-[3-fluoro-5-(pyridin-3-yloxy)phenyl]-1H-isoindole-1,3(2H)-dione；4-Fluoro-2-(3-fluoro-5-pyridin-3-yloxyphenyl)isoindole-1,3-dione
• CAS: 1245607-33-3
• 化学式: C₁₉H₁₀F₂N₂O₃
• 分子量: 352.297
• InChiKey: YYZLPPLWLMJPBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59.5
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] NOVEL ISOINDOLIN-1-ONE DERIVATIVE<br/>[FR] NOUVEAU DÉRIVÉ D'ISOINDOLIN-1-ONE
  申请人：BANYU PHARMA CO LTD

  公开号：WO2010104195A1

  公开（公告）日：2010-09-16

  The present invention relates to a compound represented by formula (I): (wherein R1, R2, R3 and R4 each independently represent a hydrogen or halogen atom; R5 and R6 each independently represent a hydrogen atom or lower alkyl or together represent oxo; X represents C(O) or the like; Y represents an oxygen atom or the like; Z represents a hydrogen atom or the like; R represents 5- or 6-membered heteroaryl having 1-3 hetero atoms selected from the group consisting of nitrogen, sulfur and oxygen atoms, contained within a ring, or the like) or to a pharmaceutically acceptable salt thereof.

  本发明涉及一种由式(I)表示的化合物：（其中R1、R2、R3和R4分别独立表示氢原子或卤素原子；R5和R6分别独立表示氢原子或较低的烷基或一起表示氧代；X表示C(O)或类似物；Y表示氧原子或类似物；Z表示氢原子或类似物；R表示含有1-3个异原子（选自氮、硫和氧原子）的5-或6元杂环芳基，包含在环内，或类似物）或其药学上可接受的盐。
• NOVEL ISOINDOLIN-1-ONE DERIVATIVE
  申请人：Arakawa Keisuke

  公开号：US20110312976A1

  公开（公告）日：2011-12-22

  The present invention relates to a compound represented by formula (I): (wherein R, R 2 , R 3 and R 4 each independently represent a hydrogen or halogen atom; R 5 and R 6 each independently represent a hydrogen atom or lower alkyl or together represent oxo; X represents C(O) or the like; Y represents an oxygen atom or the like; Z represents a hydrogen atom or the like; R represents 5- or 6-membered heteroaryl having 1-3 hetero atoms selected from the group consisting of nitrogen, sulfur and oxygen atoms, contained within a ring, or the like) or to a pharmaceutically acceptable salt thereof.

  本发明涉及一种由式(I)表示的化合物：（其中R、R2、R3和R4分别独立地表示氢或卤素原子；R5和R6分别独立地表示氢原子或低级烷基或一起表示氧代基；X表示C（O）或类似物；Y表示氧原子或类似物；Z表示氢原子或类似物；R表示包含在环中的具有1-3个异原子（选自氮、硫和氧原子）的5-或6元杂环芳基或类似物），或其药学上可接受的盐。
• US8362052B2
  申请人：——

  公开号：US8362052B2

  公开（公告）日：2013-01-29