1-[4-amino-6-(4-1H-pyrazol-1-ylphenyl)-[1,3,5]-triazin-2-yl]-3-phenylurea | 1563186-38-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[4-amino-6-(4-1H-pyrazol-1-ylphenyl)-[1,3,5]-triazin-2-yl]-3-phenylurea
• CAS: 1563186-38-8
• 化学式: C₁₉H₁₆N₈O
• 分子量: 372.389
• InChiKey: HEGBDESGSKXNBQ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  1-[4-amino-6-(4-1H-pyrazol-1-ylphenyl)-[1,3,5]-triazin-2-yl]-3-phenylurea 、 异氰酸苯酯 以 neat (no solvent) 为溶剂， 反应 1.0h， 生成 N-[4-[(C-hydroxy-N-phenylcarbonimidoyl)amino]-6-(4-pyrazol-1-ylphenyl)-1,3,5-triazin-2-yl]-N'-phenylcarbamimidic acid
  参考文献：
  名称：

  Microwave-assisted selective and efficient synthesis of 1,3,5-triazinyl mono and bisureas

  摘要：

  An efficient and sustainable microwave-assisted approach for the one-step preparation of a wide range of 1,3,5-triazinyl mono- and bisureas has been developed, combining solvent-free conditions and microwave irradiation. In these conditions the very unreactive amino groups of 1,3,5-triazine-2,4-diamines successfully react with phenylisocyanate to yield selectively mono and bisureas.This protocol resulted in the shortest reaction times reported so far and is generally applicable for the preparation of these valuable heterocyclic systems. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.01.043
• 作为产物：
  描述：

  6-(4-pyrazol-1-ylphenyl)-[1,3,5]-triazine-2,4-diamine 、 异氰酸苯酯 以 1,4-二氧六环 为溶剂， 反应 0.58h， 以70%的产率得到1-[4-amino-6-(4-1H-pyrazol-1-ylphenyl)-[1,3,5]-triazin-2-yl]-3-phenylurea
  参考文献：
  名称：

  Microwave-assisted selective and efficient synthesis of 1,3,5-triazinyl mono and bisureas

  摘要：

  An efficient and sustainable microwave-assisted approach for the one-step preparation of a wide range of 1,3,5-triazinyl mono- and bisureas has been developed, combining solvent-free conditions and microwave irradiation. In these conditions the very unreactive amino groups of 1,3,5-triazine-2,4-diamines successfully react with phenylisocyanate to yield selectively mono and bisureas.This protocol resulted in the shortest reaction times reported so far and is generally applicable for the preparation of these valuable heterocyclic systems. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.01.043