| 1609559-04-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 1609559-04-7
• 化学式: C₁₂H₁₄N₄O₂
• 分子量: 246.269
• InChiKey: SSVSCGHNQVMWHP-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 ammonium acetate 、 溶剂黄146 作用下， 生成 Ethyl 5-aminopyrido[3,4-B]pyrazine-8-carboxylate
  参考文献：
  名称：

  A Versatile Annulation Route to Primary-Amino-Substituted Naphthyridine Esters

  摘要：

  A straightforward four-step synthesis of primary-amino-substituted naphthyridine esters from commercially available cyanopyridines was described. The route makes use of a condensation reaction between pyridinyl acetates with N,N-dimethylformamide dimethylacetal (DMF-DMA) to form ortho-cyano vinylogous carbamates. These intermediates can undergo facile cyclization with ammonium acetate in acetic acid to generate the corresponding naphthyridine esters in good synthetic yields. The synthesis of primary-amino-substituted 7-azaquinoxaline was also described.

  DOI：

  10.1055/s-0033-1340111
• 作为产物：
  描述：

  Diethyl 2-(3-cyanopyrazin-2-yl)propanedioate 在 lithium chloride 作用下， 以 四氢呋喃 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  A Versatile Annulation Route to Primary-Amino-Substituted Naphthyridine Esters

  摘要：

  A straightforward four-step synthesis of primary-amino-substituted naphthyridine esters from commercially available cyanopyridines was described. The route makes use of a condensation reaction between pyridinyl acetates with N,N-dimethylformamide dimethylacetal (DMF-DMA) to form ortho-cyano vinylogous carbamates. These intermediates can undergo facile cyclization with ammonium acetate in acetic acid to generate the corresponding naphthyridine esters in good synthetic yields. The synthesis of primary-amino-substituted 7-azaquinoxaline was also described.

  DOI：

  10.1055/s-0033-1340111