2-(3-chlorophenyl)-4-(4,5-diphenyl-4H-1,2,4-triazol-3-ylsulfanylmethyl)-3-methyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-one | 1260400-87-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(3-chlorophenyl)-4-(4,5-diphenyl-4H-1,2,4-triazol-3-ylsulfanylmethyl)-3-methyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-one
• 英文别名: 2-(3-Chlorophenyl)-4-(4,5-diphenyl-4h-1,2,4-tri-azol-3-ylsulfanylmethyl)-3-methyl-6,7-dihydro-2h-pyrazolo[3,4-d]pyridazin-7-one；2-(3-chlorophenyl)-4-[(4,5-diphenyl-1,2,4-triazol-3-yl)sulfanylmethyl]-3-methyl-6H-pyrazolo[3,4-d]pyridazin-7-one
• CAS: 1260400-87-0
• 化学式: C₂₇H₂₀ClN₇OS
• 分子量: 526.021
• InChiKey: SMGXIUWVQMPOFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  ethyl 1-(3-chlorophenyl)-4-[2-(4,5-diphenyl-4H-1,2,4-triazol-3-ylsulfanyl)-1-oxoethyl]-5-methyl-1H-pyrazole-3-carboxylate 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以83%的产率得到2-(3-chlorophenyl)-4-(4,5-diphenyl-4H-1,2,4-triazol-3-ylsulfanylmethyl)-3-methyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-one
  参考文献：
  名称：

  Synthesis of 2-Aryl-4-(R-sulfanylmethyl)-3-methyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-ones

  摘要：

  Bromination of ethyl 1-aryl-4-acetyl-5-methyl-1H-pyrazole-3-carboxylates gave ethyl 1-aryl-4-(bromoacetyl)-5-methyl-1H-pyrazol-3-carboxylates which were used to alkylate benzenethiol and heterocyclic thiones at the sulfur atom. Reactions of the resulting S-alkylation products with hydrazine or methylhydrazine involved closure of pyridazine ring to afford 2-aryl-3-methyl-4-[phenyl(or hetaryl)sulfanylmethyl]-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-ones.

  DOI：

  10.1134/s1070428010100192

文献信息

• Synthesis of 2-Aryl-4-(R-sulfanylmethyl)-3-methyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-ones
  作者：V. S. Matiichuk、M. A. Potopnyk、N. D. Obushak

  DOI：10.1134/s1070428010100192

  日期：2010.10

  Bromination of ethyl 1-aryl-4-acetyl-5-methyl-1H-pyrazole-3-carboxylates gave ethyl 1-aryl-4-(bromoacetyl)-5-methyl-1H-pyrazol-3-carboxylates which were used to alkylate benzenethiol and heterocyclic thiones at the sulfur atom. Reactions of the resulting S-alkylation products with hydrazine or methylhydrazine involved closure of pyridazine ring to afford 2-aryl-3-methyl-4-[phenyl(or hetaryl)sulfanylmethyl]-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-ones.