trans-4-[{3-[(6-hydroxyhexyl)oxy]propyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate | 1346762-92-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trans-4-[{3-[(6-hydroxyhexyl)oxy]propyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate
• CAS: 1346762-92-2
• 化学式: C₂₆H₃₉NO₅S₂
• 分子量: 509.731
• InChiKey: UUBKLPMIDOOWHM-HZCBDIJESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.79
• 重原子数：
  34.0
• 可旋转键数：
  15.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  79.23
• 氢给体数：
  2.0
• 氢受体数：
  8.0

文献信息

• New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
  申请人：Almirall, S.A.

  公开号：EP2386555A1

  公开（公告）日：2011-11-16

  The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

  本发明涉及具有β2肾上腺素受体激动剂和M3肌样受体拮抗剂双重活性的新化合物，包含它们的药物组合物，它们的制备过程以及它们在呼吸疗法中的应用。
• NEW CYCLOHEXYLAMINE DERIVATIVES HAVING beta2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES
  申请人：Prat Quinones Maria

  公开号：US20130053359A1

  公开（公告）日：2013-02-28

  The present disclosure relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

  本公开涉及具有β2肾上腺素受体激动剂和M3胆碱能受体拮抗剂双重活性的新化合物，包含它们的制药组合物，它们的制备过程以及它们在呼吸疗法中的应用。
• NEW CYCLOHEXYLAMINE DERIVATIVES HAVING ß2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES
  申请人：Prat Quinones Maria

  公开号：US20130281415A9

  公开（公告）日：2013-10-24

  The present disclosure relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

  本公开涉及具有β2肾上腺素受体激动剂和M3胆碱能受体拮抗剂双重活性的新化合物，含有它们的制药组合物，它们的制备过程以及它们在呼吸疗法中的使用。
• NEW CYCLOHEXYLAMINE DERIVATIVES HAVING 2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES
  申请人：Almirall S.A.

  公开号：EP2569308A1

  公开（公告）日：2013-03-20
• NEW CYCLOHEXYLAMINE DERIVATIVES HAVING BETA2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES
  申请人：Almirall S.A.

  公开号：EP2569308B1

  公开（公告）日：2016-11-23